"A higher proportion of the women taking hormone replacement therapy had cardiovascular events than women in the control groups, " they said.
Some tout the benefits of hormone replacement therapy for menopausal symptoms, while others emphasize the risks.
Then in 2002 a single study of 16, 000 women blew all those other results out of the water, finding that hormone replacement therapy increased the risk of heart attacks by 29%.
The proof, apparently, that taking hormone replacement therapy does significantly increase the risk of breast cancer.
Two years ago, the same studies showed that hormone replacement therapy didn't prevent disease.
Let's look at one of the biggest changes in medical practice of the past decade: the decision to stop putting millions of postmenopausal women on hormone replacement therapy, which postulated that replacing the estrogen and progesterone their bodies were no longer making would do them long-term good.
Once upon a time, maybe three decades ago, people thought hormone replacement therapy was the fountain of youth for women going through menopause.
In the early 1990s, as executive vice president of American Home Products, he helped devise a strategy to defend the firm's Premarin hormone-replacement therapy--derived from pregnant mares' urine--against generic competition.
In the early 1990s, as executive vice president of American Home Products, he helped devise a strategy to fend off the firm's Premarin hormone-replacement therapy--derived from pregnant mares' urine--from generic competition.
Although a number of studies have looked at what happens to breast tissue when women start using hormone replacement therapy, the impact of continuing and discontinuing hormone use has not been well understood.
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Northern Ireland drug company Galen Holdings plan to launch a ring for delivering hormone replacement therapy in Britain over the next few months.
The question now, Hsia says, is whether hormone replacement therapy provides a demonstrable improvement in quality of life.
The team studied over 2, 500 women involved in hormone replacement therapy - whose average age was 66.
The researchers, from the University of Florida in Gainesville, carried out the study after observing that post-menopausal women under hormone replacement therapy were protected against strokes.
As an execuitive vice president at American Home Products , now called Wyeth (nyse: WYE - news - people ), Hassan helped hatch a plan that protects Premarin, a hormone replacement therapy, from generic competition on the grounds that its formula is too distinct to easily copy.
It didn't evaluate any plant-based or compounded kinds of hormone replacement therapy, and I think that it skewed the discussion of estrogen replacement in such a way that now, probably many women are really afraid to touch it with a 10-foot pole, no matter how much they suffer.
Fiona Kirkwood, cardiac nurse for the British Heart Foundation, said recent randomised studies had shown that combined hormone replacement therapy (oestrogen and progesterone) did not provide any protective benefit to women for coronary heart disease.
Women who are being treated for breast cancer are often prohibited from using traditional hormone replacement therapy because breast cancer can be sensitive to estrogen, the predominant female hormone.
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Many menopausal women who are afraid that hormone replacement therapy could increase their risk of breast cancer have turned to the herbal supplement black cohosh an alternative in recent years.
He suggested hormone replacement therapy was unlikely to be responsible since few of those involved in the study had taken HRT.
This comes on top of new evidence that Prozac, Paxil and other antidepressants cause suicidal thoughts in children and recent findings that hormone replacement therapy, touted for decades as a panacea for menopause, could increase the risk of heart attacks, strokes, breast cancer and dementia.
The older studies were all studies that merely followed women who chose on their own whether or not to take hormone-replacement therapy.
Estrogen hormone replacement therapy seemed to have all sorts of benefits based on observational studies, but they vanished under the more rigorous lens of controlled clinical trials.
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