In October the 38-year-old Harrison knocked out Scott Belshaw to win the Prizefighter heavyweight tournament.
BBC: Audley Harrison faces Michael Sprott for European title
He last fought when winning the Prizefighter heavyweight tournament last October.
Rogan won the heavyweight Prizefighter tournament earlier this year and is unbeaten in 11 bouts.
And while the reception was slightly more forgiving for the Londoner after disposing of Belshaw, then Danny Hughes and finally Coleman Barrett to claim victory in the latest Prizefighter series, his doubters remain.
And that could come in the form of Prizefighter promoter Barry Hearn, who told BBC Sport after Friday's victory that he is trying to arrange a deal with Harrison.
Harrison won gold in the super-heavyweight division at the Sydney Olympics, but four defeats in eight fights left his career in the balance before Prizefighter offered him a route back.
Rogan, 37, achieved some notoriety by winning the recent heavyweight 'Prizefighter' tournament at London's York Hall and is unbeaten in paid 10 fights.
The 1998 Commonwealth Games champion reignited his career by winning Prizefighter last year and then scored a 12th-round knockout against Michael Sprott to win the EBU heavyweight title in April.
There have been seven previous Prizefighter events but Williams will be the first current British champion to participate.
"Prizefighter has brought boxing back to the people, " said Hearn.
Barrett's victory set the tone for a night of upsets at Prizefighter, a contest that saw eight heavyweights compete in a succession of three-round bouts, beginning with four back-to-back quarter-finals, followed by semis and a final.
His father had been, among other things, a prizefighter at country fairs, more or less on the wrong side of the law all his life.
Prizefighter has been growing with each event and moving the night from Bethnal Green's York Hall to the 5, 000 capacity ExCel Arena in Docklands because of ticket demand is testimony to this.
Yes, Harrison won Friday's Prizefighter event and rightly told BBC Sport when asked about the quality of opponent that all he can do is "beat the men put in front of me".
And Harrison, who has now lost four times in his 27-fight career, including a points defeat to previous Prizefighter champion Martin Rogan last December, knows that anything other than victory will be the final nail in his coffin.
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