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These are all significant changes.
BBC: NEWS | Business | EU clamps down on airline fares
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How significant are these changes?
FORBES: Side Effects May Include
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What we found interesting is that despite these changes, a significant number of marketers have yet to reach out to their IT cohorts and tap into their expertise.
FORBES: IBM's State of Marketing Survey Says: CMOs and CIOs Must Partner
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These changes mark a significant shift in public opinion.
BBC: guns
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Crises such as these are often a crucible for significant changes in how business operates.
FORBES: Supply Chain Lessons From Japan
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Along with these broader features, there are significant changes to Office 365's programs, which include Word, PowerPoint, Excel, Outlook, OneNote, Publisher and Access.
WSJ: Review of Office 365: A Fresh New Office Finds a Place in the Cloud
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But these small changes resulted in some really significant improvements.
WHITEHOUSE: The First Lady Takes On Childhood Obesity
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The men in these couples, she discovered, exhibited significant changes in their levels of cortisol, testosterone (the principal male sex hormone, and thus in some sense the masculine equivalent of estradiol) and prolactin over the courses of their partners' pregnancies.
ECONOMIST: Hormones and fatherhood
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The consequences of these changes are severe and have had a significant negative impact on private companies and their investors.
FORBES: The Case For Private Company Stock Marketplaces
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So the change in town centres that is required is significant and will require public and private sectors coming together to find ways of financing these changes.
BBC: High Street taskforce aims to to rejuvenate retail
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If the answer to any of these questions is -- as the Center believes to be the case -- "no, " then significant changes to H.
CENTERFORSECURITYPOLICY: Center For Security Policy
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We chose to look at the period between 1970 and 1980 and then again between 2002 and 2012, because these time frames both had big deficits and loose monetary policy, and they straddle the time in which the most significant changes to the CPI methodology took effect.
FORBES: Doubting The Big Lie That Inflation Is Not A Threat