Most of Pfizer's big sellers are aging, with many losing patent protection, causing sales to crumble.
But support for this idea began to crumble almost as soon as it became public.
The irresistible logic, we claimed, was for economic reform and for the regime to crumble.
Vital clues about what caused the bridge to crumble may be lying in the Mississippi River.
Now the barriers they had sought to erect between philosophy and science began to crumble.
Money was raised to replace Mr Fielding's old sandstone grave memorial after it started to crumble away.
Embassytown, that outpost of the colonial power of Bremen, is starting to crumble under its own weight.
Religious tolerance began to crumble, culminating seven years later in the outbreak of the 30 Years War.
It would have been easy for Wales, short on confidence and experience, to crumble after the early setback.
Now what is trying to be built is only a very shaking security pillar, and it's about to crumble.
The myth of China's infinitely cheap, and as some factory owners hoped, infinitely exploitable labour is beginning to crumble.
When the edifices of society begin to crumble, a tyrant will surface to offer subservience in the guise of security.
Oh, I know I'm going to crumble and I'm trying to stay humble but I never think before I sing.
Pepsi President John Sculley, whom Jobs had picked as a mentor, ousted him in 1985--and the company began to crumble.
During the year, we saw some of the main pillars of 20th century management starting to crumble and even collapse.
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Social media stumbles can cause a brand to crumble, while, positive approaches to social networking platforms can grow your brand beyond expectations.
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The report got him into hot water, but Ackman was eventually proven right as MBIA began to crumble amid the financial crisis.
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The turmoil in European currency markets that fall of 1992 was proof for Thatcher that a united Europe was meant to crumble.
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All that began to crumble on October 2nd 1944, the day of the first public demonstration of mechanical cotton-picking in Clarksdale, Mississippi.
Muller almost added a fourth when he raced clear only to be denied by a fine block by Valdes as Barcelona began to crumble.
He waited until the economy began to crumble in 2007 and then set about snapping up loans jettisoned by struggling banks and desperate investors.
If commodity prices were to fall, forcing these state enterprises to slash expenses like their private-sector brethren, the state-capitalist model might begin to crumble.
But now that foundation is beginning to crumble, and if the trend is not reduced, the 50-year-long ascendency of the region could be threatened.
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The only bright spot for Japan last quarter was consumption, but personal spending cannot remain high if the rest of the economy continues to crumble.
BP's share price merely slid, rather than plummeted, to a 13-year low, although the stock of Tony Hayward, the firm's beleaguered boss, continues to crumble.
Mr Allawi believes that cracks in the regime are widening so fast that only small-scale American military action may be necessary for it to crumble.
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Thanks to these companies the old restrictions have started to crumble.
When the Greek monetary system earlier this year looked more ready to crumble than the Parthenon, observers from Goldman Sachs to BlackRock issued gloomy outlooks.
It is unlikely to crumble like Netscape, the most recent start-up to vie to become a new platform, since hypervisors are much harder to replace than browsers.
In other words, If Livestrong was going to crumble under the mountain of scandals and deception now synonymous with Armstrong, it probably would have happened by now.
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