The same thing occurred as the cell phone evolved from a substitute for telephone land-lines and handsets to a substitute for cameras, calculators, music players, game players, personal digital assistants and much more.
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Fifteen years ago, he was also singing with a local opera company when he got a call to substitute for a singer at the Sydney Opera House.
At the same time that Amgen is getting ready to launch its own biosimilars, Amgen and other biotechs are campaigning state governments to make it harder to substitute a biogeneric for a brand.
But there are enough players in a squad for every player to have a substitute to switch in for them whenever they want, as often as they like.
Short of going au natural, the best strategy for savings is to find a cheaper substitute for the expensive drug you are now taking.
The combination of turbocharging and high-pressure direct injection allows Ford to substitute a smaller engine for a bigger one.
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The product, offered through an arm of the fund company that sells personalized investment advice, is designed to be a substitute for conventional index funds.
And the (OFF-MIKE) indication that one was not meant to be a substitute for the other can be found in Article I, section three, clause seven of the Constitution.
In court papers, the AP argued that Meltwater paid nothing for its distribution of hundreds of thousands of excerpts of AP articles each year, a process it said was designed to serve as a substitute for AP stories.
Sports television, which started out in the 1950s as a crude but meaningful alternative to going to a game, was surely no adequate substitute for the die-hard football fan who wanted to be in the stadium.
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Denmark's rejection this September of a referendum to substitute the euro for the Danish krone should have been a wakeup call for Prodi and other European politicos.
My go-to Saturday morning recipe is an old one that owes its pleasant acidic edge to a shot of white vinegar a substitute for what would have been sour milk in thriftier times, when cooks were loathe to let any ingredient go to waste.
In doing so, it distorts precedent, it misapplies the relevant constitutional principles, it announces legal rules that will obstruct efforts by state and local governments to deal effectively with the growing resegregation of public schools, it threatens to substitute for present calm a disruptive round of race-related litigation.
Employees who do not incur expenses for cleaning products and equipment in connection with their jobs for Employer D, or who do not properly substantiate such expenses to Employer D, continue to receive the lower hourly compensation and do not receive any reimbursement and are not compensated in another way (for example, with a bonus) to substitute for the reduction in the hourly compensation.
If the U.S. government permits such flim-flams as parent-to-subsidiary laterals and barter arrangements as a substitute for cash to circumvent ILSA (and, any other sanction regime), it can forget about having sanctions serve in the future as an effective policy alternative to generally ineffectual diplomatic demarches and draconian military responses.
The president accuses the opposition of resorting to mudslinging as a substitute for policies.
When financial planner Rick Gornto devised the Alternate Plan in 1981, he wanted it to be a complete substitute for Social Security.
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However, IRS rules for 990s do not appear to allow such notices as a substitute for mandatory tax-return disclosures.
The presentation of this financial information is not intended to be considered in isolation or as a substitute for, or superior to, the financial information prepared and presented in accordance with GAAP.
The researchers associated increases in multidrug-resistant MRSA in the hospital with excessive use of two specific classes of antibiotics often prescribed to treat pneumonia (fluoroquinolones) and offered as a substitute for patients allergic to penicillin (macrolides).
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So as he came back into the UK, this was picked up by the immigration authorities and the assumption was that the returning boy was a substitute either for a boy unrelated to the family or for one of the mother's nephews.
Jacobs thinks most companies will use PORTAL as a stepping-stone to the public markets, not a substitute for them.
Dutch giants PSV Eindhoven battled back to earn a 2-2 draw away to Sparta Prague in the Czech capital, as substitute Jonathan Reis to equalize twice for the visitors -- the second a penalty in injury-time after Bony Wilfried fouled Danko Lazovic.
It would be a mistake to think of geo-engineering as a substitute for curbing carbon-dioxide emissions not merely because of the acidification of the oceans, but also because if you ever stop fertilising the oceans or spraying the atmosphere or whatever, the problem will rapidly return.
What he really needed was to find a long term substitute for the medicine he craved.
Respect, in fact, seems to be offered as a substitute for affection.
"That need remains unfulfilled and they can't handle it, and so they turn to trying to become famous as a substitute for the satisfaction for this basic need, " he said.
So banks that help small companies will receive what looks like a big subsidy (the interest rate charged will be 0.75%, unless - which is about as likely in the coming months as me being asked to come on as a substitute for Arsenal - the Bank of England increases the Bank Rate from 0.5%).
"The fear for exhibitors early on was that home entertainment would become a substitute for going to the movies, " says Marsh.
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