Pfizer has not been the only drug firm facing a patent challenge on its top seller.
Pfizer's top seller, the cholesterol drug Lipitor, is the best-selling drug in the world.
In April 2011, the top seven best-selling games outsold the top seller in April 2012, she said.
The fourth (servers) is close and recently surpassed IBM as the top seller in revenue, according to IDC.
Worse, it could lose its top seller, the antibiotic Rocephin, to patent expiration in the next several years.
"It certainly has that Apple panache to it, so I'm sure it will be a top seller, " he said.
At Pfizer, sales of top seller Lipitor actually dipped slightly, while Chantix, a once-promising anti-smoking drug, saw sales plummet.
Its top seller, heartburn treatment Nexium, is often criticized for being little different from the off-patent pill it replaced.
For instance, Eli Lilly, which is up about 15% this year, is facing its own battle over its top seller, Zyprexa.
After all, if a game like Call of Duty is the top seller year over year, why do anything to change?
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That's not enough to make up for the hit coming in 2006, when Merck's top seller, the cholesterol-lowering pill Zocor, loses patent protection.
Despite his unattractive past, Garcia quickly built Ugly Duckling into the top seller and financer of used cars for people with lousy credit histories.
In 2012, those sales were nearly 240, 000 (across the three-plus Prius models) and it was the top seller across the entire state of California.
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Encouraged, they introduced the DTP vaccine, which protects children from diphtheria, tetanus and pertussis (still a top seller), followed by an anti-snake-venom serum for snakebites.
Hanaro, the country's top seller of broadband access, and its nemesis, Korea Telecom , are racing to build the world's most advanced wireless Internet infrastructure.
But to see why this is folly for the drug industry as a whole one needs look no farther than Pfizer's own top seller, Lipitor.
This is the first time in SoundScan's 21-year history that the same record has been the top seller in the first halves of any two years.
Crew debuted its first chambray suit this spring cut in a rigid Japanese variety made in the denim capital of Kojima and reports that it's already a top seller.
Even if successful, prasugrel won't rival Plavix in time to make up for the losses Lilly faces when top seller Zyprexa, a schizophrenia drug, loses patent protection in 2011.
That also is creating doubts about whether Pristiq will be approved as an antidepressant, a major concern since Wyeth's top seller, the antidepressant Effexor XR, is expected to go generic next year.
Yingli Green Energy, just off a scorching fourth quarter in which it was the top seller of commercial and residential solar panels in California, is taking its show to the East Coast.
The toy, with its gray screen, red frame and two white knobs that are twisted back and forth to create drawings, was launched in 1960 and became the top seller that holiday season.
But the company's projected rebound this year counts on that top seller, and revisions to the Civic which was bruised by a poor review from Consumer Reports magazine to claw back market share and shore up its profit margins.
It is the biggest seller of pens and markers in the world and the top seller of picture frames, but it has made scant effort to squeeze suppliers or move production to Asia or Mexico to lower costs.
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