The biotech is actually restricting Avastin sales now to cut down on unapproved use.
In fact, the biggest blow to what doctors say is evidence of unapproved use of Natrecor.
The unapproved lines of business include banking, farming, hotels, restaurants and professional services (like engineering consulting).
They followed allegations about fraud, unapproved bonuses and failures to deal with staff grievances.
Unapproved use is at best worrying and unfair, and at worst dangerous and immoral.
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The drug giant admitted promoting two antidepressant drugs for unapproved uses, including treatment of children and adolescents.
Such papers have been used in the past to encourage doctors to prescribe medicines in unapproved ways.
So far, they are critical, seeing potential for heart risk in unapproved Cox-2 drugs developed by Novartis and Merck .
And the review gives Medicare plenty of ammunition not to pay for off-label, or unapproved, uses of Provenge.
Costa Cruises said on Monday that the route deviation last Friday had been "unauthorised, unapproved and unknown to Costa".
"Henke's interview with the newspaper was unapproved by our media liaison team, " family spokesman Arnold Pistorius, Henke's brother, said.
As we noted Tuesday, in December 2012 the IRS illegally leaked the organization's still-unapproved application to the left-leaning website ProPublica.org.
This request will be bolstered by the powerful Hollywood lobby that works hard to control the unapproved sharing the Internet allows.
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Of all of Millennium's (nasdaq: MLNM - news - people ) unapproved drugs, this one is farthest along.
That temptation must be even worse for small firms whose prospects are tied to the approval of a single unapproved drug.
While experts say the U.S. drug supply remains safe, unapproved drugs can enter through purchases from Internet pharmacies or unauthorized suppliers.
The evidence in general is good, not great, and the evidence for unapproved uses is downright bad, which is to say, nonexistent.
Normally, the agency would have banned the sale of older, unapproved drugs.
The security industry has long warned that jailbreaking iPhones to install whatever unapproved applications the user wants leaves the device open to cybercriminals.
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Most Natrecor sales at one point came from an unapproved use: Hoping to help less sick patients, doctors were giving it in clinics.
The problem for drugmakers is that they cannot market their medicines for unapproved uses without running afoul of the FDA and the law.
Parents can now hand over their phones to the kids without worrying about deleted photos, misdirected emails, unapproved purchases or accidental phone calls.
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Federal and state prosecutors regularly sue drugmakers for overcharging government health programs, marketing drugs for unapproved uses and other criminal or civil offenses.
In February the FDA warned POM it was marketing its juice as an unapproved drug and demanded it tone down its sales pitch.
However, the data from PrivacyChoice show that several dozen widely used apps are using unapproved companies, most notably Google, the biggest online ad company.
The fact that it left from this course is due solely to a manoeuvre by the commander that was unapproved, unauthorised and unknown to Costa.
This device was returned significantly less than unapproved devices and ultimately saved Cincinnati Bell an estimated half a million dollars in support, retail, and logistics costs.
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It doesn't cover the scores of other factories that sometimes wind up with retailers' orders after authorized factory owners subcontract the deals to other, unapproved manufacturers.
The firms have been charged with marketing drugs for unapproved uses, paying illegal kickbacks to raise sales, or both, cheating the public-health programmes that foot the bill.
Those serving in classified units also must do their part, holding themselves and their peers to the highest standards, reversing the trend of unapproved tell-alls from operators.
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