But the drug "hits a lot of targets, and one concern is to make sure you are not inducing an untoward effect in people who are not as severe as kids with progeria, " Dr. Collins said.

WSJ: Progeria Drug Study Helps in Search for Clues on Aging

The fact that such exceptions must be authorized on a case-by-case basis, however, offers some basis for ensuring that they are made deliberately and on the basis of merit -- and do not have the untoward effect of undermining the sanctions in place.

CENTERFORSECURITYPOLICY: Center For Security Policy

The promise (made by lawyers to patients) of some major payout should the patient have some untoward effect of surgical and medical care (as offered by a greedy legal system in front of a jury of people who would rather be texting or working) has to end.

FORBES: Avik Roy's Health Cost Fantasy

It would be great to have a new drug that had a wonderful effect on lowering cardiovascular risk with incurring any untoward risks.

FORBES: Merck Does The Right Thing