Munos says the companies that have done best made very big bets in untrammeled areas of pharmacology.

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But ignoring ecological concerns can have a real, tangible cost - one that may outweigh any extra benefits from untrammeled development.

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That was especially surprising in Sudan, the most foreign place of all, a land of vast deserts, untrammeled pyramids and vibrant mosques.

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Mr. Arroyo's Mystic Lamb fuses untrammeled, even indulgent, idiosyncrasy with heartfelt homage.

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The alternative, we are told, is that the Navy will have to take risks to assert our rights to untrammeled innocent passage.

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In five years we have opened 37 different guerrilla shops with nonfashion partners in unheard-of places or in parts of cities hitherto untrammeled.

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But I prefer Lil Wayne in untrammeled mixtape mode, and there's plenty of that on the new release as well, especially the slightly pricier deluxe version.

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