Van der Sar then dropped a Brunt cross to allow Somen Tchoyi to equalise.
Georgios Samaras then brought a fine save from Edwin van der Sar with a crisp volley.
BBC: Wayne Rooney celebrates putting Man Utd ahead in the derby
He startled keeper Edwin van der Sar, who was left motionless by the Russian's emphatic 20-yard shot.
Yossi Benayoun should have done better than head the loose ball tamely at Edwin van der Sar.
In addition, midfielder Owen Hargreaves and keeper Edwin van der Sar are undergoing treatment for knee injuries.
He beat Van der Sar with his curling effort, but it rebounded off an upright to safety.
This time Van der Sar got the better of Viduka, spreading himself to make a good save.
BBC: SPORT | Football | Premiership | Man Utd 1-1 Middlesbrough
Drogba eventually took aim and was only denied by a magnificent save by Edwin van der Sar.
The 24-year-old has also been considered as a long-term replacement for Edwin Van der Sar at Manchester United.
Arsenal's only response was a low 20-yard shot from Fabregas that was comfortably collected by Edwin van der Sar.
With penalties looming, he played a one-two with Frank Lampard before poking the ball past Edwin van der Sar.
United goalkeeper Edwin van der Sar suffered double vision as a result of the tear gas fired into the stand.
BBC: SPORT | Football | Europe | Uefa launches Man Utd crush probe
Former Netherlands goalkeeper Van der Sar, who moved to Old Trafford from Fulham in 2005, turns 40 on 29 October.
Ibrahimovic, misfiring until the 40th minute, pulled the ball back for Adriano but Edwin van der Sar sniffed out the danger.
Stephen Ireland also came on for the injured Claudio Reyna, and he swiftly brought another important save from Van der Sar.
BBC: Wayne Rooney celebrates putting Man Utd ahead in the derby
Chelsea responded, with Van der Sar twice denying the lively Sturridge but unable to prevent Kalou from slotting home a rebound.
Better work from Earnshaw saw the Welshman fashion an opening after nine minutes, but Van der Sar was equal to the shot.
In a first half of few chances, Javier Hernandez shot wide and Martin Petrov hit a free-kick at Edwin van der Sar.
The ball fell to Vassell and he powered in at the second attempt after his first strike was blocked by Van der Sar.
Edwin van der Sar is close to signing a new contract with Manchester United after deciding to play on beyond his 40th birthday.
United then survived a melee in the area after Van der Sar misjudged Bellamy's corner, with both Vieira and Onuoha unable to apply the finishing touch.
"Google is sending out a strong signal that they are committed to combating online copyright infringement, " wrote TorrentFreak's editor Ernesto van der Sar.
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After Gabriel Agbonlahor hit an early chance straight at Edwin van der Sar, Ashley Young's tackle prevented Ji-Sung Park from giving United the lead.
He mis-hit his shot, but it lofted invitingly into the path of Benayoun, who headed straight at Van der Sar from only six yards.
Martin Petrov slid a defence-splitting pass into Stephen Ireland's clever run and his poked shot was blocked by on-rushing keeper Edwin van der Sar.
Benfica's confidence was growing, and Van der Sar was in action again as he dived to his left to save from the dangerous Simao.
BBC: SPORT | Football | Europe | Manchester United 2-1 Benfica
Benni McCarthy's shot was well saved by Edwin van der Sar and substitute Kalinic fired into the net with the referee's assistant waving for offside.
Ronnie Wallwork's shot then caused further consternation for Fulham as it was parried by Van der Sar and Earnshaw was only just unable to convert.
Xavi was the creator with a cross that looked too high for Messi, but he expertly soared to send a header over Van der Sar.
Gerrard released Kuyt on the right, leaving Torres to escape from Vidic and Ferdinand to plant a firm header beyond the reach of Van der Sar.
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