Slader has chosen to veer away from the traditional non-profit course education start-ups tread.

FORBES: An Apple for the iPad? Technology & Education Start-Ups

Still, for Mr. Newell, the changing winds in the scientific research shouldn't give Johns Hopkins the ability to veer away from his aunt's wishes.

WSJ: Donated Land Is Battlefield

Plus there are times when the prices of ETFs veer away from the value of the underlying holdings, which can eat into or add to an investor's return.

WSJ: ETFs for Investors Who Buy and Hold