【译】I型干扰素是病毒引起的致命性血管损伤的治疗目标。
Type I interferon is a therapeutic target for virus-induced lethal vascular damage.
第一组基因能制造出被称为1型干扰素的分子，其作用是抵抗病毒。
The first of these produces molecules called Type 1 interferons, whose role is to fight off viruses.
格鲁曼和同事们把I型和II型干扰素基因转入一种腺病毒中，这种腺病毒是他们注射到多群猪中的。
Grubman and his colleagues introduced type I and type II interferon genes into an adenovirus, which they administered to groups of pigs.
不幸的是，干扰素在全球并不能普遍获得，并不总是耐受良好，有些基因型比其它基因型反应更好，而且许多使用干扰素治疗的人并未完成其疗程。
Unfortunately, interferon is not widely available globally, is not always well tolerated, some genotypes respond better than others, and many people who take it do not finish their treatment.
提示干扰素治疗时，基因型不能作为一个疗效的预测指标。
背景有基因1型丙型肝炎病毒（HCV）感染，但对聚乙二醇干扰素α和利巴韦林疗法没有持续应答的病人，复治成功的可能性低。
Background Patients with genotype 1 hepatitis C virus (HCV) who do not have a sustained response to therapy with peginterferon alfa and ribavirin have a low likelihood of success with retreatment.
背景有基因1型丙型肝炎病毒（HCV）感染，但对聚乙二醇干扰素α和利巴韦林疗法没有持续应答的病人，复治成功的可能性低。
Background Patients with genotype 1 hepatitis C virus (HCV) who do not have a sustained response to therapy with peginterferon alfa and ribavirin have a low likelihood of success with retreatment.
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