本文总结了近十几年来立体控制性合成含手性磷酸酯基的寡核苷酸类似物的进展，重点介绍了寡核苷酸硫代磷酸酯和甲基膦酸酯的立体控制性合成方法。
In this review, the progress of stereocontrolled synthesis of P-chiral analogues of oligonucleotides was summarized with the emphasis on oligonucleotide phosphorothioates and methylphosphonates.
本文总结了近十几年来立体控制性合成含手性磷酸酯基的寡核苷酸类似物的进展，重点介绍了寡核苷酸硫代磷酸酯和甲基膦酸酯的立体控制性合成方法。
In this review, the progress of stereocontrolled synthesis of P-chiral analogues of oligonucleotides was summarized with the emphasis on oligonucleotide phosphorothioates and methylphosphonates.
应用推荐