格鲁曼和同事们把I型和II型干扰素基因转入一种腺病毒中，这种腺病毒是他们注射到多群猪中的。
Grubman and his colleagues introduced type I and type II interferon genes into an adenovirus, which they administered to groups of pigs.
不幸的是，干扰素在全球并不能普遍获得，并不总是耐受良好，有些基因型比其它基因型反应更好，而且许多使用干扰素治疗的人并未完成其疗程。
Unfortunately, interferon is not widely available globally, is not always well tolerated, some genotypes respond better than others, and many people who take it do not finish their treatment.
第一组基因能制造出被称为1型干扰素的分子，其作用是抵抗病毒。
The first of these produces molecules called Type 1 interferons, whose role is to fight off viruses.
提示干扰素治疗时，基因型不能作为一个疗效的预测指标。
【译】I型干扰素是病毒引起的致命性血管损伤的治疗目标。
Type I interferon is a therapeutic target for virus-induced lethal vascular damage.
背景有基因1型丙型肝炎病毒（HCV）感染，但对聚乙二醇干扰素α和利巴韦林疗法没有持续应答的病人，复治成功的可能性低。
Background Patients with genotype 1 hepatitis C virus (HCV) who do not have a sustained response to therapy with peginterferon alfa and ribavirin have a low likelihood of success with retreatment.
背景有基因1型丙型肝炎病毒（HCV）感染，但对聚乙二醇干扰素α和利巴韦林疗法没有持续应答的病人，复治成功的可能性低。
Background Patients with genotype 1 hepatitis C virus (HCV) who do not have a sustained response to therapy with peginterferon alfa and ribavirin have a low likelihood of success with retreatment.
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