目的：构建丙型肝炎病毒(HCV)全长及3种不同缺失突变的核心蛋白基因的原核表达载体，并在大肠杆菌中表达。
AIM: to construct the recombinant plasmids expressing full-length HCV core protein gene and 3 different deletion mutated hepatitis core protein genes and to express them in E. coli.
科学家发表在《基因组研究》杂志的文章说，锁钥机制的核心分子是一个叫做CTCF的蛋白。
The molecule at the heart of the lock-and-key mechanism is a protein called CTCF, say the scientists in a paper published in the journal Genome Research.
这意味着它由一种蛋白质核心颗粒病毒基因组内有它的形式双链脱氧核糖核酸。
Meaning that it consists of a proteinaceous core particle that has the viral genome inside of it in the form of double stranded DNA.
组蛋白是染色质的核心，其尾部共价修饰在基因表达调控中有重要作用。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
核心蛋白在一个特定基因型的方式和IRS1退化。
Core protein and IRS1 degradation in a genotype - specific manner.
目的：比较B，C两种基因型HBV核心蛋白在促进肝细胞凋亡方面的差异，以期初步阐述HBV基因型与临床关系的发病机制。
AIM: To compare the proapoptosis effect of hepatitis B virus (HBV) genotype B and C core proteins on liver cells, and explore the pathogenesis of HBV infection with different genotypes.
人们很早就注意到，真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。
It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.
目的：研究抑癌基因PTEN在人肝细胞肝癌中的表达及其与HCV核心蛋白间的关系。
Objective: To study the relationship between PTEN expression and HCV core protein in hepatocellular carcinoma (HCC).
当研究人员向突变细胞内加入人造泛素——一种组蛋白复合物后，细胞恢复正常，表明这的确是Brca1基因的核心功能。
When the researchers added artificial ubiquitin-histone complexes to the mutant cells, the cells recovered, suggesting this was indeed the Brca1 gene's core function.
当研究人员向突变细胞内加入人造泛素——一种组蛋白复合物后，细胞恢复正常，表明这的确是Brca1基因的核心功能。
When the researchers added artificial ubiquitin-histone complexes to the mutant cells, the cells recovered, suggesting this was indeed the Brca1 gene's core function.
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