Methods: Gradient PCR was employed in analysis of aldosterone synthase (CYP11B2) gene polymorphisms, and gel Imaging Technology was used to determine the optimal annealing temperature.

方法：采用梯度PCR对醛固酮合酶基因(CYP11B2)进行扩增，通过凝胶呈像技术判断CYP11 B2基因最佳退火温度。

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Aldosterone secretion is regulated largely at the level of expression of the final enzyme required for its biosynthesis, aldosterone synthase (CYP11B2).

醛固酮合酶(CYP11B2)是醛固酮生物合成最后一步的催化酶。醛固酮的分泌主要由醛固酮合酶的表达水平来调节。

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Several genetic polymorphisms of the aldosterone synthase gene (CYP11B2), which may influence the plasma aldosterone levels, had been reported to influence the blood glucose levels.

醛固酮合成酶基因(CYP11B2)部分位点的多态性改变除导致血浆醛固酮水平发生改变外，还与血糖变化密切相关。

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Several genetic polymorphisms of the aldosterone synthase gene (CYP11B2), which may influence the plasma aldosterone levels, had been reported to influence the blood glucose levels.

醛固酮合成酶基因(CYP11B2)部分位点的多态性改变除导致血浆醛固酮水平发生改变外，还与血糖变化密切相关。

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