All of the 2,4 pyrrolindinediester derivatives were reduced with lithium aluminum hydride in anhydrous THF, and ten new chiral 2,4 Dihydroxylmethylpyrrolidine derivatives were found.
然后，在无水THF中用氢化铝锂还原，得纯的手性2 ，4 二羟甲基四氢吡咯衍生物。
The synthesis of key intermediate of Gliclazide can be improved by using Potassium borohydride instead of Lithium aluminum hydride. The procedure is suitable for industrial production.
本文对格列其特的中间体氮杂双环盐酸盐的合成工艺进行了改进，使工艺更适合工业化大生产的要求。
The synthesis of key intermediate of Gliclazide can be improved by using Potassium borohydride instead of Lithium aluminum hydride. The procedure is suitable for industrial production.
本文对格列其特的中间体氮杂双环盐酸盐的合成工艺进行了改进，使工艺更适合工业化大生产的要求。
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