Objective to determine the gene regulation of androgen receptor (AR).
目的:研究雄激素受体(AR)的基因调控。
The key is something called a selective androgen receptor modulator, or SARM.
关键是所谓选择性雄激素受体调节剂,或行动情报处。
This invention provides a class of androgen receptor targeting agents (ARTA).
本发明提供一类雄激素受体靶向剂(ARTA)。
Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%.
对201摘录,11人已被发现,以遏止雄激素受体活性的40 %以上。
The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM).
该试剂定义新一亚类化合物,它们是选择性雄激素受体调节剂(SARM)。
Compounds of structural formula (I) are modulators of the androgen receptor (ar) in a tissue selective manner.
结构式(i)的化合物是组织选择性的雄激素受体(AR)调节剂。
METHODS The percentage of androgen receptor positive cells were detected by fluorescence activated cell sorter (FACS).
方法应用荧光激活细胞分离器(FACS)检测雄激素受体阳性的细胞。
To develop an androgen receptor (AR) reporter gene assay in which the reporter gene is chloramphenicol acetyltransferase (CAT).
建立以氯霉素乙酰化酶(CAT)为报告基因的雄激素受体(AR)报告基因试验。
Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.
已发现几种SARM化合物具有意外的雄激素受体之非甾族配体的促雄性和合成代谢活性。
Objective:To investigate the relationship between the polymorphic CAG short-tandem repeat(STR) at the androgen receptor(AR) gene exon 1 and lung cancer.
目的:探讨人雄激素受体(AR)基因第一外显子CAG串联短重复序列(STR)多态性与肺癌发生之间的关系。
Results: some genes including several genes on Y chromosome and androgen receptor gene were demonstrated to be associated with spermatogenesis impairment.
结果:Y染色体上的一些基因、雄性激素受体基因等被证实与生精障碍相关。
Objective: to probe the role of androgen receptor (ar) and insulin receptor (INSR) in pathogenesis of asymmetric polycystic ovaries (PCO) as local factors.
目的:探讨雄激素受体(AR)和胰岛素受体(INSR)在不对称性多囊卵巢(PCO)局部发病机制中的作用。
Objective:To study the relationship between polymorphism of (CAG)n repeats within androgen receptor gene with severe oligozoospermia or azoospermia patients.
目的探讨无精或严重少弱精症患者与雄激素受体基因(CAG)n重复多态性的关系。
Objective to study the relativity of the CAG polymorphisms of androgen receptor gene of the patients with acne and syndrome differentiation and typing of TCM.
目的探讨雄激素受体基因CAG多态性与痤疮中医分型的相关性。
Objective: To explore the relationship between CAG microsatellite polymorphism of androgen receptor gene and hyperandrogenism of polycystic ovary syndrome (PCOS).
目的探讨雄激素受体基因微卫星CAG多态性与多囊卵巢综合征(PCOS)患者高雄激素血症的关系。
To study the clinical features and the role of androgen receptor (ar) and insulin receptor (IR) in auto-para endocrine control of asymmetric polycystic ovaries (PCO).
探讨不对称性多囊卵巢(PCO)的临床特点及雄激素受体(AR)和胰岛素受体(IR)在其发病机制中的作用。
The mutation of androgen receptor gene, abnormal phosphorylation and abnormal regulation of co-activators contribute to the formation of androgen-independent prostate cancer.
雄激素受体基因突变、多种途径引起的异常磷酸化激活和共激活物的调节失控等是激素非依赖性前列腺癌形成的主要促成因素。
Objective to study the clonality of palmar fibromatosis by molecular genetic analysis of X chromosome inactivation pattern at a polymorphic site of human androgen receptor gene (HUMARA).
目的通过人雄激素受体(HUMARA)基因位点克隆性分析技术确定掌纤维瘤病是否为肿瘤性增生。
CONCLUSIONS Androgen can autoregulate the expression of androgen receptor in MCF-7 breast cancer cell line. Flutamide and hydroxyflutamide up regulate the expression of androgen receptor.
结论MCF-7乳腺癌细胞株中雄激素受体存在自动调节,氟他胺和羟基氟他胺上调雄激素受体的表达。
AIM: To study the role of androgen receptor (AR) in hormone-dependent and hormone-independent prostate cancer cell proliferation by knocking down AR expression with adenovirus-delivered siRNA.
目的:利用RNA干涉技术抑制雄激素受体(AR)的表达,研究AR在激素依赖性和激素非依赖性前列腺癌细胞增殖中的作用。
Most likely there are multiple genes that contribute towards MPB, the most important of which appears to be the Androgen Receptor gene, located on the X chromosome (inherited from the mother).
大多数论证认为多基因会引致雄性脱发,而其中最为重要的的是雄激素受体基因,该基因位于X性染色体(对于男性来说遗传自母亲)。
Conclusion: androgen receptor gene CAG microsatellite polymorphism exists in Chinese women does not significantly relate with pathogenesis of hyperandrogenism and is not the main cause of PCOS.
结论中国汉族雄激素受体基因微卫星CAG多态性对PCOS高雄激素血症的形成无明显关系,不是PCOS的主要致病因素。
Conclusions Androgen receptor gene CAG length showed polymorphism in older men, most of the CAG length focused on 21-24. This study offered the basic data on relationship for AR gene and disease.
结论自然人群中老年男性雄激素受体基因CAG重复序列呈现多态性,多数集中在21 - 24,为进一步研究AR基因变异与疾病的关系提供依据。
Basically what it does is up-regulate PGE2 which AIDS in hair growth, suppresses androgen receptor related functions, promotes maintenance, and significantly improves the functions of hair follicles.
目前来看,它的作用是上调前列腺素e2(一种帮助头发生长的激素),同时能够抑制雄激素受体的相关功能,促进和保护了头发毛囊的生长。
Basically what it does is up-regulate PGE2 which AIDS in hair growth, suppresses androgen receptor related functions, promotes maintenance, and significantly improves the functions of hair follicles.
目前来看,它的作用是上调前列腺素e2(一种帮助头发生长的激素),同时能够抑制雄激素受体的相关功能,促进和保护了头发毛囊的生长。
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