In the super early phase of acute cerebral ischemia, many therapeutic drugs cannot penetrate into the complete blood-brain barrier (BBB) and enter brain tissues within the effective time window.
在急性脑缺血的超早期，完整的血脑屏障(BBB)使许多治疗药物无法在有效治疗时间窗内进入脑组织发挥作用。
Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).
目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。
Objective To explore the effect of thrombin (TB) on the blood brain barrier(BBB) permeability and its possible mechanism.
目的探讨凝血酶（TB）对血脑屏障通透性的影响及其可能机制。
Reactive oxygen species (ROS) are mediators of demyelination and disruption of the blood-brain barrier (BBB).
活性氧簇(ROS)是神经系统脱髓鞘及血脑屏障破坏的媒介。
The increase of blood-brain barrier (BBB) permeability is a key link in causing the pathological changes in vasogenic brain edema and inflammatory reaction.
血脑屏障通透性增高是造成血管源性脑水肿和炎症反应等病理学变化的主要环节。
Aim: To compare the functional difference between two kinds of blood-brain -barrier (BBB) models in vitro.
目的：比较两种不同体外血脑屏障(BBB)模型的功能差异。
NP-SLE patients with local CNS involvements showed mainly the damage of blood brain barrier(BBB) .
相反，局限性CNS受损患者主要表现为血脑屏障（BBB）破坏。
Objective To study the influence of microwave radiation on the structure and function of blood-brain barrier (BBB) in rats.
目的研究微波辐射对大鼠血脑屏障(BBB)结构与功能的影响。
Objective To probe role of contrast-enhanced MRI in assessing damage of blood-brain barrier (BBB) during reperfusion after occlusion of right middle cerebral artery in rats.
目的通过对大鼠局灶脑缺血再灌注的研究评价增强MRI在判定血脑屏障损伤中的作用。
Objective To investigate the changes of blood brain barrier (BBB) after severe craniocerebral trauma.
目的研究颅脑创伤后血脑屏障(BBB)的改变。
Objective To study the change in blood-brain barrier (BBB) permeability in dog with craniocerebral gunshot injury and its significance.
目的探讨犬脑枪弹伤后血脑屏障(BBB)通透性改变及意义。
The Evans blue EB was used to test the permeability of blood brain barrier BBB.
用伊文思蓝测定血脑屏障的通透性。
There existing blood-brain-barrier(BBB) problem, a variety of potential drugs for curing the illness of nerve center system(NCS) are restricted in the process of drug application.
由于血脑屏障的存在，许多神经中枢系统疾病的潜在治疗药物在应用中受到限制。
But it is difficult for exogenous gene to enter brain because of the presence of the blood-brain barrier (BBB). This is the main obstacle for gene transfer therapy in central nervous system.
但血脑屏障的存在却使外源性基因难以进入脑内，是中枢神经系统转基因治疗的主要障碍。
The research on factors affecting Blood-Brain Barrier(BBB) is paid more and more attention by most researchers.
对血脑屏障影响因素的研究越来越受到人们的关注。
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB).
本发明涉及用于靶向传递治疗剂穿过血脑屏障(BBB)的高效人工低密度脂蛋白(LDL)载体体系。
AIM: To construct 3d QSAR models of drugs passing through the blood brain barrier (BBB), that provide a theoretical basis for molecular drug design.
目的：建立药物透过血脑屏障的三维构效模型，为药物分子设计提供理论依据。
AIM: To construct 3d QSAR models of drugs passing through the blood brain barrier (BBB), that provide a theoretical basis for molecular drug design.
目的：建立药物透过血脑屏障的三维构效模型，为药物分子设计提供理论依据。
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