Thus, the NEU-induced primary chromosome breakage may not be repaired by the ligase.
由NEU所诱发的染色体初级断裂不能为连接酶所修复。
Rearrangement — Chromosome breakage followed by reconstitution in an abnormal combination. If unbalanced, the rearrangement can produce an abnormal phenotype.
染色体结构改变造成遗传物质的重新排列。若为非平衡型重排，则可导致异常表型。
Cells from at patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage (3, 4).
来自AT病人的细胞显示有缺陷的DNA损伤诱导检验点激活，对放射的敏感性和频率较高的染色体断裂(3,4)。
If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.
双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。
There existed DNA breakage, apoptotic body, chromosome aggregation and the changes of related apoptotic gene expression in the AD brain.
AD脑组织易损区存在着DNA断裂损伤，凋亡小体，染色质凝集及凋亡相关的基因表达改变。
There existed DNA breakage, apoptotic body, chromosome aggregation and the changes of related apoptotic gene expression in the AD brain.
AD脑组织易损区存在着DNA断裂损伤，凋亡小体，染色质凝集及凋亡相关的基因表达改变。
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