All four dengue virus (DENV) serotypes were permanently in circulation, though the predominant serotype has alternated between DENV-3 and DENV-2 since 2000.
尽管2000年之后主导血清型在DENV - 3和DENV - 2之间交替，但是全部四种登革热病毒血清型一直在循环着。
The NS3 protein with good immunogenicity appears to be a dominant target for dengue virus-specific CD4+ and CD8+ T cells, and most dengue virus NS3-specific T cells are serotype cross-reactive.
NS3具有良好的免疫原性，存在多个登革病毒特异性CD4+、CD8+T细胞表位，且多具有型间交叉免疫特性。
The NS3 protein with good immunogenicity appears to be a dominant target for dengue virus-specific CD4+ and CD8+ T cells, and most dengue virus NS3-specific T cells are serotype cross-reactive.
NS3具有良好的免疫原性，存在多个登革病毒特异性CD4+、CD8+T细胞表位，且多具有型间交叉免疫特性。
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