Despite In spite of this, I prefer the second.
但尽管如此，我还是更喜欢第二个。
I went out despite (or in spite of) the rain.
虽然下着雨，我还是出了门。
For all / In spite of / Despite the disadvantages/ side effect, it has its compensating advantages / beneficial effects.
尽管存在一些缺点/负面影响，但它并非一无是处。
Despite (or In spite of) mistakes and weaknesses, it is a good composition.
尽管有错误和不足，这还是一篇好作文。
Despite (or In spite of) mistakes and weaknesses, it is a good composition.
尽管有错误和不足，这还是一篇好作文。
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