Defects in DNA damage response can cause genome instability, which induces many human cancers.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
In this way, studying the efficacy of DNA damage response inhibitors on HBV infection and replication was available.
通过这种方式，研究DNA损伤反应抑制剂对于HBV感染和复制的作用成为可能。
In particular, dysfunction in DNA damage response and repair is a common feature in many human cancers, including colon cancers.
特别是，DNA损伤反应和修复的功能障碍是人类许多癌症的一个共同特征，其中包括结肠癌。
Deacetylation of p53 occurs through interaction with the SIRT1 protein, a deacetylase that may be involved in cellular aging and the DNA damage response (19).
SIRT1蛋白，一种涉及到细胞衰老和DNA损伤反应的去乙酰基酶能够与p53结合，促使后者的去乙酰化（19）。
However, some investigators demonstrated that glioma stem cells are radiosensitive with a defective DNA damage response compared with established glioma cell lines.
但是最近有研究表明，胶质瘤干细胞并不一定比传统胶质瘤细胞系抗拒。
Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability.
多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。
The research team led by Professor, Zhong from Beijing Institute of Biotechnology used report that HBV infection activates and exploits the DNA damage response to replication stress.
该研究小组的负责人钟教授来自北京生物技术学院，他曾经报道过HBV感染可以激活并利用DNA损伤修复机制来应对复制的压力。
The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of DNA damage response and DNA repair.
乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。
The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of the DNA damage response and DNA repair.
乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。
We have designed a strategy to select new drug targets that inhibit a cellular gene required for HBV replication or restore a response stalled by HBV in the ATR DNA damage pathway.
筛选新的药物靶点可以通过抑制HBV复制必需的一个基因或者保持HBV所引起的AT R损伤途径中的一种失调反应。
Similarly, the cellular response to the environmental mutagens is not always initiated by DNA damage.
同样地，环境诱变剂诱发的细胞应答反应也不只是单纯地由DNA损伤所触发的。
Objective to explore the cellular response of human senescent diploid fibroblasts (2bs) to the DNA damage caused by methyl methanesulfonate (MMS).
目的观察衰老的人胚肺二倍体成纤维细胞(2bs)对烷化剂甲磺酸甲酯(MMS)诱导的DNA损伤的应答。
In response to DNA damage, the complex cellular mechanisms including cell cycle arrest, transcription induction and DNA repair are activated.
为了应对DNA损伤，细胞有一套复杂的机制，包括细胞周期停滞，诱导转录和DNA修复被激活。
The SOS response of Escherichia coli is a classic model system for studying DNA damage repair response and there has been plenty of quantitative datas about it.
大肠杆菌的SOS反应作为研究DNA损伤修复反应的经典模式系统，已积累了大量观测数据。
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations.
p53肿瘤抑制蛋白在细胞响应DNA损伤和其它基因组异常的过程中发挥重要作用。
Phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and activation of p53 in response to DNA damage (4, 7).
P53的磷酸化削弱了MDM2的结合，从而促进了它的激活和累积以响应DNA损伤(4,7)。
An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
细胞对DNA损伤作出应答的一个重要过程是检查点活化(检查点激酶CHK1和CHK2使关键蛋白磷酸化，从而阻止正常的细胞周期。)
Modulation of the DNA-damage response, depending on where in the network this modulation occurs, could have different consequences including chemosensitization and chemoprotection.
根据调控在这个网络中发生作用的位置，DNA损伤-应答的调控可能产生不同的结果，这包括化学感受性和化学保护两方面。
However, further studies have indicated that they are actually DNA-damage-response kinases, regulating more than just cell-cycle checkpoints.
进一步的研究表明它们事实上是DNA损伤-应答激酶，不仅仅是调控细胞周期的检查点。
However, further studies have indicated that they are actually DNA-damage-response kinases, regulating more than just cell-cycle checkpoints.
进一步的研究表明它们事实上是DNA损伤-应答激酶，不仅仅是调控细胞周期的检查点。
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