Correlation analysis was processed among serum folate concentration of dam and fetus and DNA methylation level in fetal brain.
期末血清叶酸、胎鼠血清叶酸及胎鼠脑组织DNA甲基化水平作相关分析。
DNA methylation is an important regulation of gene express in eukaryotic cells, and is one of the most common modifications of the transcription level.
DNA甲基化是基因表达的重要调控方式，是真核细胞中最常见的转录水平的修饰方式之一。
Under usual conditions, there is an inverse correlation between gene expression level and DNA methylation. The gene can be silenced by DNA promoter methylation.
通常情况下，基因表达水平与DNA甲基化呈负相关，基因启动子区域甲基化从而导致该基因沉默。
Conclusions:The HPLC method that we have established for assaying the genome-wide DNA total methylation level is stable and reproducible;
结论：本文所建立的高效液相色谱法能够准确灵敏地检测全基因组总体甲基化水平，检测结果稳定，方法重现性好；
Conclusions:The HPLC method that we have established for assaying the genome-wide DNA total methylation level is stable and reproducible;
结论：本文所建立的高效液相色谱法能够准确灵敏地检测全基因组总体甲基化水平，检测结果稳定，方法重现性好；
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