The effect of Oxymatrine(OMT), isolated from Sophora flavescens Ait, on the hepatic microsomal drug-metabolism enzyme have been investigated.
氧化苦参碱是自中药苦参中提取的一种生物碱，本文就其对小鼠肝微粒体药物代谢酶的影响进行了探讨。
The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
药物的溶解性，在胃肠道中的稳定性，膜的通透性和全身代谢是影响口服药物吸收的主要因素。
There's a growing awareness that we need to more carefully consider obesity and other factors that affect drug absorption, distribution, metabolism and other factors.
人们越来越多的意识到，其应该认真研究肥胖以及其他因素对药物的吸收、分布、代谢和其他方面的影响。
Balaglitazone has been evaluated in a series of preclinical efficacy pharmacology, safety pharmacology, pharmacokinetic/toxicokinetic, and drug metabolism studies.
巴格列酮已经经过一系列临床前期药效药理学、安全药理学、药代动力学或毒性动力学和药物代谢研究的评估。
Decreased peripheral blood flow also alters drug distribution and metabolism.
外周血流减少也会改变药物的分布和代谢。
From the handful of studies on the effects of pomelo on drug metabolism, it looks like pomelo and pomelo juice act much like grapefruit and grapefruit juice.
根据少数关于柚子对药物代谢影响的研究，看起来柚子和柚子汁像葡萄柚和葡萄柚汁一样起作用。
Grapefruit and pomelo aren't the only fruits that affect drug metabolism.
葡萄柚和柚子不是影响药物代谢的唯一水果。
The drug also sped up metabolism and turned harmful white fat that wobbles around the waist into healthy brown fat.
它还能加速新陈代谢，将腰部多余而有害的白色脂肪转化为健康的棕色脂肪。
It's a drug to normalise metabolism that has, as an added benefit, weight loss. The public must be very, very clear about that.
它只是一种能使代谢更正常的药物，作为额外效果，就是减肥。公众对此一定要非常非常清楚。
OBJECTIVE: To observe the effect of the capsule on NO metabolism on arterial wall in rabbits and explore the improvement of such drug on myocardial blood flow and protection on myocardium.
目的观察胸痹通胶囊对家兔动脉壁一氧化氮代谢的影响，探讨该药改善心肌血液灌流、发挥心肌保护作用。
Conclusion Due to significant first pass metabolism, the drug was mainly existed in the form of glucuronidated genistein in the plasma.
结论染料木黄酮首过代谢突出，血浆中药物主要以葡糖醛酸结合形式存在。
Courses of study include mammalian physiology and pharmacology, drug metabolism, neural control, oncology, and other topics.
学习课程包括哺乳动物生理学，制药学，药品的新陈代谢，神经控制，肿瘤学和其他学科。
The expressions of the various genes modulated cell growth and proliferation, apoptosis, cell cycle, stress response, transporters, chaperones, transcription regulation and drug metabolism.
差异表达的基因的功能涉及细胞生长增殖调控、凋亡、细胞周期、应激反应、转运及代谢酶等方面。
CONCLUSION In situ liver perfusion is an appropriate organ model for drug metabolism and disposition research.
结论大鼠原位肝灌流是良好的整体器官药物代谢模型，是体外实验有力的补充。
Choosing the suitable drugs and dosages according to cytochrome P450 and drug metabolism would improve the pharmacotherapy efficacy and reduce the adverse drug reaction and toxic effect of drugs.
根据细胞色素P 450和药物的生物转化来选择合适的药物及合适的剂量将有助于最大程度地提高药物治疗效应，同时减少药物不良反应和毒副作用。
CYP450 is regulated by genetic genes. Once the gene mutates, the CYP450 enzyme that coded and the drug metabolism then will change.
CYP450的合成受着遗传基因的调控，一旦基因发生变异，它所调控合成的CYP450酶及酶所催化的药物代谢即发生变化。
CYP3A29 is the most important key enzyme for drug metabolism in pig's liver.
CYP3A29是猪肝脏最重要的药物代谢关键酶。
This review provides a better understanding of the cytochrome P450 system with a focus on those enzymes most involved in drug metabolism.
这次综述提供了一个对大多数药物代谢有关的酶为重点的细胞色素P 450系统的了解。
There are differences in drug metabolism, differences in drug clearances and when they interact like that you can have frightening problems in terms of adverse reactions.
药物的代谢和清除存在差异且当他们像这样相互时，就不良反应而言可能会出现可怕的问题。
Drug metabolism enzymes (DME) play a significant role in drug detoxification and activation, which exert important effect on drug efficacy and sensitivity to toxicity.
药物代谢酶(DME)在药物代谢解毒和药物代谢活化中起着重要的作用，对组织器官的药物效应和毒性的易感性产生重要影响。
When renal function declined, drug excretion slow, and drug metabolism altered.
肾功能减退时，不但药物排泄缓慢，而且药物代谢也会发生改变。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
The adverse drug interactions can be avoided by knowing the enzymology basis of drug metabolism, common substrates, inductors, inhibitors involved and using the same kind of drugs rationally.
认识药物代谢的酶学基础，了解药酶的常见底物、诱导剂和抑制剂，合理选用同类药品，能避免有害药物代谢性相互作用的发生。
The drug ACTS by essentially reprogramming the metabolism of cancer cells, re-teaching them to undergo apoptosis, or cell death.
它可以重组癌细胞的新陈代谢，重新教会癌细胞如何死亡。
Decreased peripheral blood flow also alters drug distribution and metabolism.
血流减少也会改变药物的分布和代谢。
Cytochrome P450 enzyme are an important enzyme family in drug metabolism.
色素氧化酶p 450是药物代谢中的一个重要的酶系。
CONCLUSION Active recombinant human CYP2B6 obtained using baculovirus expression system will facilitate further examination of the role of this enzyme in drug metabolism.
结论杆状病毒表达系统能成功表达有活性的CYP2B6重组酶，可用来进一步研究在药物代谢中的作用。
Inhibition of CYP can lower the metabolism of another drug, which may elongate or enhance its effects and increase adverse reactions and even cause deformity-inducing and deadly medical incidents.
后者使CYP受到抑制，使另一药物的代谢减少，轻者延长或加强其作用、增加不良反应，重者引发致残或致命的医疗事故。
Inhibition of CYP can lower the metabolism of another drug, which may elongate or enhance its effects and increase adverse reactions and even cause deformity-inducing and deadly medical incidents.
后者使CYP受到抑制，使另一药物的代谢减少，轻者延长或加强其作用、增加不良反应，重者引发致残或致命的医疗事故。
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