RESULTS The influx of water that passed the osmotic pump tablet was greatly less than the drug dissolution rate from tablet core and the bergenin release rate.
结果水透膜的速率远小于片芯中药物的溶出速率及岩白菜素渗透泵片的释药速率;
Surfactants increase the dissolution rate by increasing the wetability, solubility, and dispersibility of the drug.
表面活性剂通过增加药物的吸湿性、溶解度和分散性来增加其溶解速率。
Objective: Drug dissolution is rate and degree of dissolution which is from solid dosage forms such as tablets and capsules so on at specified solvent.
目的:药物溶出度系指药物从片剂或胶囊等固体制剂或半国体制剂在规定的溶剂中溶出的速度和程度。
OBJECTIVE The solid dispersion method was adopted to enhance the dissolution rate of nifedipine (NFDP) which is a poorly water-soluble drug.
目的采用制剂技术提高难溶性药物硝苯地平体外溶出速率。
CONCLUSION The dissolution rate of NFDP can be improved greatly by solid dispersions with proper ratio of drug and carrier.
结论药物与载体合适比例的固体分散物明显提高其体外溶出速率。
The dissolution rate of CyA was increased dramatically after the formation of solid dispersion compared with the pure drug powder. CONCLUSION PVP can enhance the dissolution rate of CyA dramatically.
药物从固体分散体中的溶出度比原药粉末显著提高,且随着PVP比例的增加而增大。
Dissolution rate determines the availability of the drug for absorption.
溶解速率溶解速率决定药物吸收时的可用度。
METHODS Preparing the solid dispersion by melting method at different drug-to-PEG ratios with different PEG moleculars and studying the preparation with dissolution rate in vitro and DSC method.
方法以不同分子量不同比例的聚乙二醇为载体,以熔融法制备固体分散体,并进行体外溶出度研究和DSC扫描。
METHODS Preparing the solid dispersion by melting method at different drug-to-PEG ratios with different PEG moleculars and studying the preparation with dissolution rate in vitro and DSC method.
方法以不同分子量不同比例的聚乙二醇为载体,以熔融法制备固体分散体,并进行体外溶出度研究和DSC扫描。
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