In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer.
在过去的十年里，越来越多的大量数据指出了表观改变在人类癌症中的一个关键作用。
Environmentally triggered alterations in genes - known as epigenetic changes - can affect when a gene is activated, how robustly it is turned on and how it interacts with neighboring genes.
环境所引发的基因变异被称为“表观遗传变化”，它可能会影响基因被激活的时间、被激活的程度以及它如何与邻近基因相互配合。
The EWG added that exposure can also cause epigenetic changes, meaning alterations in the way genes switch off and on and genetic changes that can be passed on to the next generation.
EWG补充说暴露在PBA下还会导致遗传性变异，意味则各种基因的变异能够遗传到一下代身上。
These results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in ALL.
这些结果扩展了白血病的基因变异谱，确定后天调控与转录靶向突变为ALL的耐药机制。
These results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in ALL.
这些结果扩展了白血病的基因变异谱，确定后天调控与转录靶向突变为ALL的耐药机制。
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