Receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCR) and ion channel receptors are main cell surface receptors.
酪氨酸激酶型受体、G蛋白偶联受体和离子通道型受体是细胞表面三类主要受体。
G Protein-coupled receptors are a group of drug targets with important physiological functions and of pathological significance.
G蛋白偶联受体具有重要的生理功能和病理意义，已成为一类重要的药物靶点。
With more than 300 members, the G protein-coupled receptors constitute the largest family of proteins found in the membranes of cells.
蛋白偶联受体家族成员超过300种，它们构成了细胞膜中最大的蛋白质家族。
G protein-coupled receptors play a critical role in heart disease, blood pressure regulation, inflammation and psychological disorders.
蛋白偶联受体在心脏病、血压调节、炎症和心理疾病中扮演关键角色。
The vast majority of these G protein-coupled receptors respond to hormones and neurotransmitters. They are not naturally abundant and tend to be structurally unstable.
这类G蛋白偶联受体中的绝大部分对激素和神经递质有反应，它们在自然中并不丰富且在结构上趋于不稳定。
The molecule is part of a large family of proteins called G-protein coupled receptors (GPCRs).
这一分子属于名为“G蛋白伴随受体”的蛋白家族。
The insect odorant receptors, as other odorant receptors from nematoid to human, have long been perceived to be G-protein-coupled receptors(GPCR).
昆虫的气味受体长久以来被认为是一种G蛋白偶联受体，遵循从线虫到人类的通用模式。
G-protein Coupled Receptors (GPCRs) belong to one of the largest superfamilies of membrane proteins and are important targets for drug design.
蛋白偶联受体属于跨膜蛋白的大家族，在药物设计中起着很重要的作用。
Lysophosphatidic acid (LPA) is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly, through G-protein coupled receptors.
溶血磷脂酸(LPA)是一种生物活性磷脂介质，主要通过G蛋白偶联受体发挥多种生物学功能。
CCR5, a membrane protein on cell surface, is a member of the G protein-coupled receptor superfamily and one of the major co-receptors for HIV-1infection.
CCR5为细胞膜蛋白，属于G蛋白偶联受体家族的成员，是HIV - 1入侵机体细胞的主要辅助受体之一。
G-protein coupled receptors do not have ion channels as part of their structure; they affect channels by activation of intermediate molecules called G proteins.
蛋白耦联受体本身并不具备离子通道；它们通过G蛋白分子介导通道的激活。
STAT proteins are activated by G-protein coupled receptors, while it has not been reported whether CCK receptors, a kind of G-protein coupled receptors, can activate JAK/STAT pathway.
STAT蛋白可被G 蛋白偶联受体激活，而CCK 受体作为一种G 蛋白偶联受体，是否对JAK／STAT通路具有直接激活作用，尚未见报道。
The molecular structure of adrenoceptor fits common model of G protein coupled receptors on membrane surface.
肾上腺素受体的分子结构符合G蛋白耦联膜表面受体的一般特征。
Also, disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
本发明还公开了检测G蛋白偶联受体核酸序列中的突变的诊断方法以及检测受体的可溶形式的改变水平的诊断方法。
Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes.
本发明公开了通过应用辅助基因的共表达来实现或改进G蛋白偶联受体的功能分析的方法。
In 1990s, molecular biological approach has led to a series of cloning and functional expression of ligand-gated P2X receptors and G-protein coupled P2Y receptors.
90年代，采用分子生物学手段，一系列配体门控的P2 X受体及G蛋白耦联的P 2y受体被克隆及功能表达。
In 1990s, molecular biological approach has led to a series of cloning and functional expression of ligand-gated P2X receptors and G-protein coupled P2Y receptors.
90年代，采用分子生物学手段，一系列配体门控的P2 X受体及G蛋白耦联的P 2y受体被克隆及功能表达。
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