Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
We will further investigate the relationship of histone modification and promoter methylation on the expression of TFPI-2.
今后，我们将在表观遗传层面对TFPI-2基因的修饰和相关组蛋白的修饰进行深入研究。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP 与 CTCF）的基因。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.
核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。
Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation.
表遗传学机制在肺癌的形成中占据重要地位，包括DNA的甲基化和组蛋白修饰，肺癌中与癌形成有关基因的失活多与异常甲基化有关，并且组蛋白修饰和甲基化紧密联系着。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.
表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。
We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching.
我们在一组人类基因中发现了与剪接结果相关的独特的组蛋白修饰特征，及组蛋白导致剪接位点转换的调节。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
组蛋白是染色质的核心，其尾部共价修饰在基因表达调控中有重要作用。
Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.
其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。
The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
The changes of histone chemical modification play definite important role in the benezen's hematopoietic toxicity.
组蛋白化学修饰可能在苯代谢物所致的造血毒性中发挥一定的作用。
The changes of histone chemical modification play definite important role in the benezen's hematopoietic toxicity.
组蛋白化学修饰可能在苯代谢物所致的造血毒性中发挥一定的作用。
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