Objective: To rationally design new inhibitors of HIV-1 integrase.
目的：合理设计新的HIV-1整合酶抑制剂。
Because of the special function of HIV-1 integrase, it has become one of focuses of anti-AIDS drug design.
由于HIV - 1整合酶的特殊功能，它已成为抗艾滋病药物设计工作的焦点之一。
Aim To synthesize a series of new caffeic acid derivatives and test their HIV-1 integrase inhibitory activities.
目的合成新型咖啡酸衍生物并测定其抑制HIV 1整合酶活性。
The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
给出了各个代表性体系的应用价值。旨在对HIV - 1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
HIV-1 integrase (in) integrates viral DNA into host cells through two steps metal ions-dependent reactions.
HIV - 1整合酶(IN)通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中。
HIV-1 integrase (in) integrates viral DNA into host cells through two steps metal ions-dependent reactions.
HIV - 1整合酶(IN)通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中。
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