Objective:To establish a SPE-HPLC method for the determination of quinapril and its active metabolite quinaprilat in human plasma and to evaluate their pharmacokinetics and relative bioavailability.
目的：建立SPE—HPLC法测定人血浆中喹那普利及其代谢产物喹那普利拉的浓度，以研究喹那普利及喹那普利拉在健康志愿者中的药代动力学和相对生物利用度。
Objective: to establish a method to determine atenolol concentration in plasma by SPE-HPLC, and to study relative bioavailability of atenolol tablet.
目的：建立血浆中阿替洛尔的固相萃取结合HPLC检测方法。对两厂家产阿替洛尔片人体相对生物利用度及生物等效性进行评价。
Objective: to establish a method to determine atenolol concentration in plasma by SPE-HPLC, and to study relative bioavailability of atenolol tablet.
目的：建立血浆中阿替洛尔的固相萃取结合HPLC检测方法。对两厂家产阿替洛尔片人体相对生物利用度及生物等效性进行评价。
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