Oligonucleotides have a wide range of applications in genetic testing.
寡脱氧核苷酸在基因检测中有着广泛的应用。
Disclosed are oligonucleotides for manipulating an immune reaction.
本发明公开了用于操纵免疫反应的寡核苷酸。
Suppose you are working with oligonucleotides 32 nucleotides in length.
假设你在用32核苷酸长度的寡核苷酸工作。
The present invention relates to regulate activity of target RNA oligonucleotides.
本发明涉及用于调节靶RNA活性的寡核苷酸。
The modified oligonucleotides overcome many problems associated with current antisense drugs.
经修饰寡核苷酸克服了与当前反义药物有关的许多问题。
However, many classes of oligonucleotides are polyanions, so they cannot cross over cell membrane.
但是，大多数此类化合物是呈负电性的，不能有效跨越细胞膜。
Important new applications that could not be performed using natural oligonucleotides have emerged.
许多重要的、用天然寡核苷酸无法实现的新应用也应运而生。
Objective To study inhibition of VEGF expression in human bladder carcinoma cells by antisense oligonucleotides.
目的观察vegf反义寡核苷酸对膀胱癌细胞VEGF表达的抑制情况。
Abstract Objective to study the inhibitory effect of PCNA antisense oligonucleotides on the growth of rat glioma.
【摘要】目的探讨增殖细胞核抗原(pcna)反义寡核苷酸对大鼠胶质瘤生长的抑制作用。
The aim of gene therapy is to transfect DNA into target cells, in which utilizing antisense oligonucleotides is a main method.
基因治疗是将DNA转染进入目的细胞，修复遗传错误或产生治疗因子。反义寡核苷酸的应用是基因治疗的主要手段之一。
Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the influenza a virus.
用于诊断流感A病毒的H5和N1基因的存在的寡核苷酸，其用途，检测方法和试剂盒。
AimTo synthesize ribonucleoside-incorporated oligonucleotides and investigate their binding abilities with complementary sequences.
目的合成异核苷掺入寡核苷酸并考察它们与互补序列的结合能力。
Objective To explore the efficiency of transfection of antisense oligonucleotides HA-2741 by ultrasound mediated liposome microbubbles.
目的探讨超声介导脂质体微气泡转染反义寡核苷酸ha- 2741的有效性。
The porphyrin moiety was modified on the commercial oligonucleotides through the active 1-hydroxybenzotriazole esters of the porphyrins.
利用卟啉的1-羟基苯并三氮唑活性酯可将卟啉基团直接修饰在商品化的寡核苷酸片断上。
Results: the abilities of antisense oligonucleotides to inhibit the cell growth of KB-A-1 mainly depended upon their targeted sequences selected.
结果：作用靶点不同的反义寡核苷酸对KB - A - 1细胞生长的抑制能力不同。
Objective: To investigate the growth inhibition of antisense oligonucleotides of telomerase on liver tumor cell enhanced by albumin nanoparticles.
目的：利用纳米载体增强端粒酶反义寡核苷酸对肝脏肿瘤细胞生长的抑制作用。
AIM: To study the effect of acyl coenzyme a: cholesteryl acyltransferase 1 (ACAT1) antisense oligonucleotides on the formation of foam cells (FC).
目的：观察酰基辅酶a：胆固醇酰基转移酶1 (ACAT1)反义寡核苷酸对泡沫细胞(FC)形成的影响。
Results VEGF antisense oligonucleotides obviously inhibited VEGF expression in human bladder carcinoma cells and proliferation of endothelial cells.
结果VEGF反义寡核苷酸对膀胱癌细胞的VEGF表达有明显的抑制作用。
"The current textbooks for medical students do not have chapters on antisense oligonucleotides, but this will change in the near future," said Thornton.
Thornton说：“目前以学生课本中没有反义寡聚核苷酸的章节，但是在不久的将来这点将改变。”
Objective To investigate the effect of IL 12 antisense oligonucleotides on immunoglobulin secretion by PBMC from patients with active lupus nephritis (LN).
目的探讨IL12反义寡核苷酸对狼疮肾炎(LN)患者单个核细胞(PBMC)分泌免疫球蛋白的影响。
Modified oligonucleotides of the invention are administrated as therapeutic agents, and hybridize to complementary sequences within targeted RNA molecules.
本发明的经修饰寡核苷酸作为治疗剂施用，并且与所针对的RNA分子内的互补序列杂交。
Compared with the unmodified one, the inhibition of antisense oligonucleotides to the growth of KB - a - 1 cell was increased by conjugating with naphthyl imide.
与单独使用反义寡核苷酸相比较，萘二酰亚胺对寡核苷酸的共价修饰显著地提高了反义寡核苷酸对KB-A -1细胞生长的抑制。
AIM: to investigate the effect of antisense oligonucleotides (ASODN) encoding telomerase reverse transcriptase (TERT) mRNA on thyroid carcinoma (TC) cell apoptosis.
目的：探讨端粒酶逆转录酶(TERT)的反义寡核苷酸(A SODN)对甲状腺癌(TC)细胞凋亡的影响。
This research attains the following achievements: (1) The universal oligonucleotides microarray has the virtues of low background and high probed binding efficiency;
通过试验，本研究获得了以下成果：（1）制作出背景低，杂交效率高的通用寡核苷酸芯片；
The aim of this article is to investigate the effects on lymphangiogenesis of orthotopic implantation of lung cancer in nude mice with antisense oligonucleotides of VEGF-C.
本研究目的旨在观察脂质体介导的VEGF - C反义寡核苷酸对肺癌裸鼠皮下种植瘤模型微淋巴管生成的影响。
During oligonucleotide immobilization, terminal amino modification has no obvious specificity, but it can enhance the hybridization capacity of immobilized oligonucleotides.
寡核苷酸固定过程中，末端氨基修饰没有明显的特异性，但是可以提高被固定探针的杂交容量。
A method of polyamide thin layer chromatography applicable to the separation and identification of blocked nucleosides, nucleotides and oligonucleotides is herewith described.
本文介绍了用聚酰胺薄层层析的方法，分离和检定带保护基的核苷、核苷酸和低聚核苷酸。
Ultraviolet crosslinking greatly affected the attachment rate of a large fragment of DNA, but did not noticeably affect the attachment rate of the amino-modified oligonucleotides.
紫外交联对大片段DNA固定率影响显著，但对氨基修饰的寡核苷酸影响不显著；
Ultraviolet crosslinking greatly affected the attachment rate of a large fragment of DNA, but did not noticeably affect the attachment rate of the amino-modified oligonucleotides.
紫外交联对大片段DNA固定率影响显著，但对氨基修饰的寡核苷酸影响不显著；
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