• Cyclic AMP binds to the regulatory subunit of protein kinase A: Protein kinase A phosphorylates phosphorylase kinase.

    腺苷酸结合蛋白激酶调节亚基一个磷酸化蛋白激酶磷酸化酶激酶。

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  • The gene IKKE produces a protein kinase also known as IKKE.

    IKKE基因可以产生一种蛋白激酶被称作IKKE。

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  • Objective To investigate the effects of increased protein kinase a (PKA) activity on the proliferation of T24 cell line and the possible mechanism.

    目的探讨蛋白激酶A (pka)活性增高膀胱癌细胞株t24增殖影响及其机制。

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  • AMP-activated protein kinase AMPK is a central component of a protein kinase cascade that plays a pivotal role in the regulation of intracellular energy status.

    调节细胞能量状态蛋白激酶级联反应中,AMP激活的蛋白激酶(AMPK中枢组成部分

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  • Objective:To observe the changes of the activity of protein kinase A(PKA) and C(PKC), and further investigate the mechanisms of anti-hypothermia action of Guizhi Tang.

    目的:研究低体温大鼠下丘脑蛋白激酶APKA)、蛋白激酶CPKC活性变化及桂枝汤的升温作用机理

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  • As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

    事实上I化合物疗法中可用于治 疗失调蛋白激酶活性相关疾病例如癌症

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  • Here, we will review several kinds of protein kinases as potential targets for CVDs and some difficulty in identifying a protein kinase as a putative therapeutic target for CVDs.

    在此我们总结一些已经能用于心血管疾病蛋白激酶靶位以及一些鉴定与心血管疾病有关蛋白激酶假定治疗靶位的难点

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  • This gene, which encodes a protein kinase and is regulated by a small molecule called cyclic GMP, has been previously studied but not suspected to play a role in sleep regulation.

    这个基因编码一种蛋白质激酶,并环状GMP分子的调节。基因以前过研究知道它有一定的睡眠调节作用

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  • AIM: To examine possible direct effects of the vasodilators hydralazine and KRN2391 on the activities of protein kinase A (PKA) , protein kinase G (PKG), and protein kinase C (PKC).

    目的研究血管扩张药酞嗪KRN2391蛋白激酶直接作用以探讨其作用机制。

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  • Cerepro harnesses an adenovirus, a type of virus which carries its DNA in double-stranded form, to transmit a gene responsible for the production of a protein called thymidine kinase.

    Cerepro被固定腺病毒(一能够携带双链形式DNA病毒)上来传染基因这个基因负责产生胸苷激酶这种蛋白质

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  • The latter encodes a novel protein kinase with LIM domains and is strongly expressed in the brain.

    后者以LIM范围编码了一个新奇蛋白质激酶并且大脑强烈地表达

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  • Mutations in GNA11 induced spontaneously metastasizing tumors in a mouse model and activated the mitogen-activated protein kinase pathway.

    小鼠模型,GNA11突变诱导自发转移肿瘤激活了丝裂活化蛋白激酶途径。

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  • Therefore, the aim of this study is to investigate the effects of genistein, a protein tyrosine kinase inhibitor, on acute and chronic inflammation in diabetic mice (induced by streptozotocin).

    因此研究目的调查金雀异黄素一种蛋白质酪氨酸激酶抑制剂对有急性慢性糖尿病炎症小鼠诱导脲佐菌素)的影响

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  • It binds and activates protein kinase c, causing a wide range of effects in cells and tissues (1, 2).

    结合激活蛋白激酶c,对很多细胞组织产生影响(1,2)。

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  • The recombinant human protein kinase CK2 may be used as a molecular target for simpler screening and development of more effective inhibitors of CK2.

    重组蛋白激酶CK2作为一种较为简便筛选开发有效CK 2抑制剂分子靶点

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  • Novel Oncogene with Kinase-domain (NOK) is a novel tumor-related gene, coding receptor like protein with a kinase domain.

    新的肿瘤相关基因,其结构上受体蛋白相似具有一个蛋白激酶结构

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  • Gefitinib is protein tyrosine kinase inhibitor of a selective EGFR, can block the signal transduction pathway of tyrosine protein kinase, and then promote tumor cell apoptosis.

    非替尼为选择性EGFR一蛋白酪氨酸激酶抑制剂阻断酪氨酸蛋白激酶信号传导通路从而促进肿瘤细胞凋亡。

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  • CONCLUSION (Kaempferol is a) novel potent inhibitor of protein kinase CK2 in vitro.

    结论山萘黄素新的体外蛋白激酶CK2有效抑制剂

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  • The core of cell cycle regulation and control mechanism are relative to a group of protein kinase.

    细胞周期调控机制核心蛋白激酶

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  • Electively targeting of signaling pathways using protein kinase inhibitors would have a potential advantage over receptor blockers.

    这种用来选择性地阻断信号转导途径蛋白激酶抑制剂可能一种潜在有利受体阻断剂。

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  • The tyrosine phosphorylated 130000 protein was identified as JAK2, a non receptor tyrosine kinase.

    鉴定了分子量为130000酪氨酸磷酸化蛋白质JAK2一种受体型酪氨酸激酶

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  • Aurora A (AIK) is a cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines (1-3).

    极光激酶AAIK种调节细胞周期的丝氨酸/苏氨酸蛋白激酶多种肿瘤细胞系中过表达(1-3)。

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  • CONCLUSIONS AG1109 not only was an effective inhibitor of protein tyrosine kinases, but also was a novel potent inhibitor of protein kinase CK2.

    结论AG110 9不仅酪氨酸蛋白激酶抑制剂而且一种十分有效的蛋白激酶CK2的抑制剂。

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  • When the high-fat diet is fed to a normal mouse, IKKE protein-kinase levels rise, the metabolic rate slows, and the animal gains weight.

    给予正常小鼠饮食后,IKKE蛋白激酶水平上升新陈代谢降低,则小鼠会长胖。

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  • Such lists can be projected onto prior knowledge of kinase-substrate interactions to infer the list of kinases associated with a specific protein list.

    这些列表能够投射激酶-底物相互作用先验知识推断一个特定蛋白质列表相关激酶列表。

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  • The encoded proteins have a number of potential N-glycosylation as well as protein kinase recognition sites, which may be involved in the regulation of peptide transport;

    编码蛋白多个N 糖基蛋白激酶识别位点它们可能参与转运的调控

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  • AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis (1).

    腺苷酸激活蛋白激酶(AMPK)一种在酵母植物动物界高度保守的蛋白激酶,它能量平衡中发挥关键性作用(1)。

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  • JAK2 is a constitutive protein tyrosine kinase (PTK) which can activate JAK-STAT signaling.

    JAK2一种组成性酪氨酸激酶激活JAK - STAT信号传导途径

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  • Thomas, PhD, of Lilly's Cancer Discovery Research division, ex- plained, "AKT1 is a protein kinase or enzyme that plays a key role in activating survival, proliferation and metabolic pathways."

    Thomas博士解析道,“AKT1一个蛋白激酶,它细胞生存增殖代谢通路活化重要作用

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  • Thomas, PhD, of Lilly's Cancer Discovery Research division, ex- plained, "AKT1 is a protein kinase or enzyme that plays a key role in activating survival, proliferation and metabolic pathways."

    Thomas博士解析道,“AKT1一个蛋白激酶,它细胞生存增殖代谢通路活化重要作用

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