Hypoxia can directly induce pyruvate dehydrogenase kinase 1 (PDHK1) expression, which results in inactivation of PDH and the TCA cycle and subsequent suppression of metabolism (4).
低氧条件会直接诱导丙酮酸脱氢酶激酶1 (PDHK1)的表达，它的表达会抑制pdh的活性和TCA循环，从而抑制了随后的代谢通路(4)。
Pyruvate generated from glycolysis is converted to acetyl-CoA by pyruvate dehydrogenase (PDH) under normoxia (1-3).
糖酵解产生的丙酮酸在正常条件下被丙酮酸脱氢酶(PDH)转化成乙酰辅酶a (1 - 3)。
Pyruvate generated from glycolysis is converted to acetyl-CoA by pyruvate dehydrogenase (PDH) under normoxia (1-3).
糖酵解产生的丙酮酸在正常条件下被丙酮酸脱氢酶(PDH)转化成乙酰辅酶a (1 - 3)。
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