It has been called in question on clinical safety, even not accepted by international market, due to toxical Semen Strychni as monarch drug which often induce adverse reaction.
但因其君药马钱子毒性较大，临床常有不良反应报道，从而影响该药的临床安全使用及国际准入。
Objective to clarify the main component of acute toxic effect in Shufeng Huoluo pills, and the effects of other components from Shufeng Huoluo pills on acute toxic effect of Semen Strychni.
目的阐明疏风活络片急性毒性作用的主要组分，以及其他组分对马钱子急性毒性的影响。
ResultsAcute toxic manifestations of Shufeng Huoluo pills were twitch, entasia, which resemble acute toxic symptoms of Semen Strychni.
结果含马钱子的疏风活络片的主要急性毒性表现为抽搐强直性痉挛，与马钱子急性中毒症状相似。
Conclusion Semen Strychni and its processed products of Jiangxi methods and innovated methods can lower the toxicity and improve the safety of clinical use.
结论江西法及其改良法炮制的马钱子比其砂烫法和油炸法更易降低毒性，使其安全范围增大，从而提高其临床用药的安全性。
Objective: Noisome gel and conventional gel of Semen Strychni alkaloids extract (SSAE) were prepared. The comparative studies of transdermal diffusion in vitro and anti-inflammation were performed.
目的： 对马钱子总碱（SSAE）囊泡凝胶和马钱子总碱凝胶进行体外透皮扩散和抗炎作用对比研究。
Objective: Noisome gel and conventional gel of Semen Strychni alkaloids extract (SSAE) were prepared. The comparative studies of transdermal diffusion in vitro and anti-inflammation were performed.
目的： 对马钱子总碱（SSAE）囊泡凝胶和马钱子总碱凝胶进行体外透皮扩散和抗炎作用对比研究。
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