The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme.
与天然存在的野生型酮还原酶相比，本公开提供了具有改善的性质的酮还原酶。
To test his hypothesis I colonized wild-type mice with B.
要检验他的假设我拓殖与细菌B。
Male wild-type mice had twice the ALT levels (P < . 05 in both cases).
雄性野生种小鼠的此数值为2倍（P <.05）。
The properties of the mutant enzyme W117Y are very different from wild-type enzyme.
突变酶w 117y的性质与野生型酶明显不同。
We found that CD8 t (CM) and t (EM) were equally effective at rejecting allografts in wild-type hosts.
我们发现CD 8T (CM)和T (EM)在其野生型宿主的排斥反应的移植物中同样有效。
Objective To study the antigenic variation of wild-type measles virus prevailing in Zhejiang Province.
目的了解浙江省麻疹野毒株的抗原性变异状况。
These mice displayed resistance to the diet, gaining significantly less weight and body fat than wild-type mice.
与野生型相比，这些小鼠显示出饮食抵触，体重增加和肥胖明显减少。
Conclusions Wild-type measles virus prevailing in Zhejiang Province has appeared significant antigenic variation.
结论浙江省麻疹野毒株已出现明显的抗原性变异。
Complete response rates were similar for children with either mutation and children with wild-type FLT3, the authors report.
作者报道，有突变患儿和野生型FLT3患儿的完全有效率是相似的。
Clinical and pathological variables, copy number alterations, mutations, and expression signatures were compared with a cohort of TCEB1 wild-type tumors.
就肿瘤的临床及病理特征、染色体拷贝数量改变、突变和表达特征等方面与TCEB1野生型肿瘤进行比较。
Recessive allelic variations were investigated at 3 microsatellite (SSR) sites within the o2 gene by using 14 inbred o2 lines and a wild-type line in maize.
用14个O2玉米自交系和1个普通玉米自交系研究玉米o2基因内3个微卫星(SSR)位点的隐性等位变异。
Female wild-type mice on an ethanol-rich diet had 4 times as much alanine aminotransferase (ALT), indicating liver injury, than mice lacking the osteopontin gene.
雌性野生种小鼠的丙氨酸转氨酶是基因敲除鼠的4倍，这提示肝损伤的存在；
Conclusion Transfection of wild-type PTEN tumor suppressor gene might significantly reduce metastatic ability of human highly metastatic mucoepidermoid carcinoma cells.
结论转染野生型PTEN抑癌基因能降低人高转移性黏液表皮样癌细胞转移能力。
The authors found that mice lacking CD24, a membrane protein expressed by immune and stem cells, developed an inflammatory response that was more powerful and lethal than that in wild-type mice.
作者们发现，缺乏CD 24，这种在免疫细胞和干细胞上表达的膜蛋白的老鼠，产生了比野生型老鼠更强且更致命的炎症反应。
Objective To study effects of the exogenous wild-type PTEN tumor suppressor gene on in vitro adhesion, migration and invasion of the highly metastatic mucoepidermoid carcinoma cell line M3SP2.
目的探讨外源野生型PTEN抑癌基因对人高转移性黏液表皮样癌细胞系m 3sp2体外黏附、迁移和侵袭特性的影响。
An important safety issue related to the varicella vaccine is the impact on the epidemiology of herpes zoster both in vaccinees as well as in individuals previously infected with wild-type varicella.
与水痘相关的一个重要的安全性问题是其对带状疱疹的流行病学的影响—这种影响既见于受接种者，也见于既往曾感染过野生型水痘的个体。
The snowshoe hare for example, a type of wild rabbit, changes color with seasons for this reason.
例如一种叫雪兔的野兔，因为这个原因，它们会随季节变化颜色。
Four cases have been confirmed to have been caused by wild poliovirus type 1 and laboratory testing continues.
经确认，四例病例由1型野生脊灰病毒引起，实验室检测还在继续。
On 20 April, four polio cases due to wild poliovirus type 1 were confirmed in Yemen.
4月20日，在也门由1型野生脊髓灰质炎病毒造成的4例脊髓灰质炎病例得到确认。
On left, red blood cells are stained in wild type zebrafish embryos while on the right mutant embryos lacking the enzyme Ago2 fail to produce blood cells.
左图，野生型斑马鱼胚胎已染上红色血细胞，而右图缺乏酶Ago2的变异胚胎则不能产生血细胞。
In addition to international spread of type 1 polio, wild poliovirus type 3 originating from northern Nigeria has also been reported in Chad and Niger.
除了在国际范围蔓延的1型脊髓灰质炎外，乍得和尼日尔也报告了起源于尼日利亚北部的3型脊髓灰质炎病毒。
Northern Nigeria is currently affected by a new outbreak of wild poliovirus type 1 (WPV1), which has begun to spread internationally.
尼日利亚北部目前受到新暴发的野生1型脊髓灰质炎病毒(WPV1)影响，此病毒已开始在国际上传播。
All three mutants showed higher luciferase activity than that of the wild type, and the V85I mutant showed the highest activity.
三个突变异种均显示比野生型具有更高的荧光素酶活性，并且V85I突变异种活性最强。
When the DNA was methylated the chromosome was able to be successfully transplanted into a wild type species of M. capricolum.
当DNA甲基化后，染色体能够顺利植入野生型的丝状支原体。
Conclusion Construction of the eukaryotic expression vectors of wild type and mutant PRPF31 genes is basic work for research on the mechanisms of retinitis pigmentosa caused by PRPF31 mutation.
结论野生型和突变型PRPF31基因真核表达载体的构建，为研究PRPF31基因突变引起视网膜色素变性的机制奠定了基础。
The variant cell line also expressed high level of cross resistance to ethionine which was 6.5 fold higher than that of the wild type.
同时还表现出对乙硫氨酸的交叉抗性，其抗性是野生型的6．5倍， 表明该抗性系抗性表达稳定。
Objective to construct the expression vectors of human cytochrome P450 (CYP) 4f2 wild type, V81G and V433M Variants and express and purify CYP4F2 protein in e.
目的构建人细胞色素P450 4f 2基因野生型、V81G和V433 M突变型表达载体，在大肠杆菌中表达并纯化出CYP4F2蛋白。
They all accumulated on the surface of rice root system in the medium with higher ammonia concentration, while the wild type strains were removed from rice root surface in the same condition.
这些转化结合子在高铵下表现出固氮活性，并能集聚在水稻根表，而野生型菌在相同条件下远离水稻根表。
The growth and maturation of the green mutant were relatively slower than the wild type.
绿色突变体的生长和成熟均比野生型慢。
But wild type GFP and EGFP are not ideal to detect the transient changes of gene expression regulation.
但野生型GFP及增强型GFP等因半衰期长，稳定性强，对反映一过性转录表达调控的变化不甚理想。
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