the ax has enlarged the borders of our settlements, and the mines, as well of iron and coal as of the precious metals, have yielded even more abundantly than heretofore.

VOA: special.2009.11.23

You're taking a normal gene and you're over expressing it or expressing it more abundantly than normal in one particular spot of the body to have an effect.

我们在讨论一个正常基因的过表达,也就是在体内某一点的表达量,大大超过正常水准从而产生疗效

耶鲁公开课 - 生物医学工程探索课程节选