It's not until Book Three of Paradise Lost that the poet explicitly reveals to us, to his readers, the fact of the physical handicap that might reasonably be thought to render impossible his composition of the poem.

直到失乐园第三卷,诗人才明确告诉读者们，自己失明的事实,这可能被合理的认为是他无法完成诗歌创作的原因。

耶鲁公开课 - 弥尔顿课程节选

because we have another handicap like language is like burden that people from here don't really have, so

因为我们也有语言上的障碍，这里的人就没有这个负担。

来自西班牙的留学生 - SpeakingMax英语口语达人

It makes it--this is a handicap to the U.S. insurance industry.

这其实是美国保险业发展的一个障碍

耶鲁公开课 - 金融市场课程节选