Later,when penicillin was widely available, the researchers denied the men the drug that could have cured their illness.
VOA: special.2010.07.21
So now, the enzyme is locked up with being built, and the penicillin has effectively killed the bacteria.
所以这是我第一次感受到,我想在单个原子的层面上思考这些分子,所以这时我的专业转到了化学方向。
Drugs like antibiotics, Penicillin, Erythromycin, again something else you probably all had experience with and you think well that's not Biomedical Engineering that's science, that's somebody discovering a molecule that kills microorganisms.
像抗生素,青霉素和红霉素这样的药物,你们都用过这些药,你不认为这属于生物医学工程的研究范围,而认为是科学的产物,科学家发现这种分子能够杀灭微生物
You could imagine strategies where you have multiple resistance genes on a plasmid, resistance to Ampicillin, to Penicillin, to Erythromycin for example, and you design strategies for separating out which cells are carrying the plasmid that you're interested in.
若质粒上有多种抗性基因,你就有很多筛选方法,例如对氨苄青霉素,青霉素,红霉素的抗性,而且你可以设计方法分离出,含有你感兴趣质粒的细胞
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