In other studies, bone marrow transplants cured severe sickle cell disease in almost two hundred children.

VOA: special.2009.12.16

It's a single gene defect and we know exactly where the genetic defect is in sickle cell.

是一种单基因缺陷,而且我们准确地知道,镰状红细胞贫血的基因缺陷在哪里

耶鲁公开课 - 生物医学工程探索课程节选

It's on the gene for hemoglobin and the hemoglobin that you produce if you have sickle cell anemia is not quite right because there's one base difference.

这个缺陷基因和血红蛋白有关,如果你有镰状红细胞贫血症,那你所产生的血红蛋白就不太正常,因为这里有一个碱基不同

耶鲁公开课 - 生物医学工程探索课程节选

People with sickle cell disease can suffer severe pain, bacterial infections and the death of tissue.

VOA: special.2009.12.16

Sickle cell anemia is a disease that affects a subset of the population.

镰状红细胞贫血症,是一种作用于特定人群的疾病

耶鲁公开课 - 生物医学工程探索课程节选

Last week,researchers in the United States reported curing nine adults with sickle cell disease.

VOA: special.2009.12.16

We talked about sickle cell anemia last time, that's an example.

上次我们讲过镰刀状贫血病,那就是一例

耶鲁公开课 - 生物医学工程探索课程节选

Black people in Africa are the huge majority of those with sickle cell disease.

VOA: special.2009.12.16

This particular example involves the gene for sickle cell anemia.

本例子中就包括镰状红细胞贫血症的基因

耶鲁公开课 - 生物医学工程探索课程节选

In a normal cell DNA that DNA in the normal cell - this DNA gets cut by the restriction enzyme, so the sickle gene ends up - so that hemoglobin gene ends up in two pieces.

一个正常细胞的DNA,正常细胞里的DNA,会被限制酶所剪切,因此镰状血红蛋白基因--,不对,是正常血红蛋白基因被切成两段

耶鲁公开课 - 生物医学工程探索课程节选