American officials say the agreement benefits both sides, and any significant change could unravel the whole deal.

VOA: standard.2009.10.20

It does seem as though people who have brushes with death change their behavior in significant ways.

确实似乎有过和死亡擦肩而过经历的人,行为会显著地改变。

耶鲁公开课 - 死亡课程节选

One of the most significant barriers to people doing things in the world, to actually introducing change is that they underestimate their ability to bring about change.

人若想在世间有所为,真正实现改变，面对的最显著障碍之一,是他们低估自己实现改变的能力。

哈佛公开课 - 幸福课课程节选

Singapore's Finance Minister Tharman Shanmugaratnam said none of the ministers called for any sudden or significant change in exchange rates, but said they should remain flexible.

VOA: standard.2009.11.12

So now we've said something about the economic change and something about the political change, and next hour, I'll start with the story of the military change that has so many significant consequences. Okay.

这节课我们讨论了经济变革,和政治变革,接下来,我们将会学到军队的变革,及其重要的历史意义,好的,下课

耶鲁公开课 - 古希腊历史简介课程节选

American Heart Association spokesman Dr.Donald LaVan explains why that change in the arteries is significant.

VOA: standard.2010.03.04

"Whether or not they blame Karzai for that personally, I think that there is a general sense among significant parts of the population that it may be time for a change.

VOA: standard.2009.08.03

"I think that you're going to see some significant additional sanctions imposed by the international community, assuming that the Iranians don't change course and agree to do the things they signed up to do at the beginning of October,".

VOA: standard.2009.12.12