When left untreated,however, it can lead to changes in a person's physical appearance and even death.

VOA: special.2010.07.06

So, polio--the disease caused by polio can be a paralytic disease, crippling, and in some cases can lead to death if the disease progresses in certain ways.

小儿麻痹症便是由脊髓灰质炎病毒引起的,如果脊髓灰质炎发展到一定程度,患者不仅会瘫痪或者残疾,一些病例甚至可能死亡

耶鲁公开课 - 生物医学工程探索课程节选

Defibrillators use electric shocks to correct abnormal heartbeats that can lead to sudden death.

VOA: special.2010.08.17