Hobrooke admits is a very complicated and difficult problem to address.

VOA: standard.2009.06.15

Well, I talked about the problem of using plasmids in gene therapy, that it's very difficult to get them into cells.

我们之前讨论过,基因治疗中运用质粒的问题,质粒本身极难进入细胞

耶鲁公开课 - 生物医学工程探索课程节选

In fact there's research-- for example, this was done with internists, doctors, who are giving a very difficult, very difficult question connected to a liver problem that an individual patient had.

实际上有这样一项研究-,在内科医生，医生中间进行，向他们提出一个，与肝脏问题有关的很困难的问题,那是一个病人的病症。

哈佛公开课 - 幸福课课程节选