-
They're making that because you need this protein insulin, it's a hormone, and it's important for sugar metabolism in your body.
它们产生胰岛素蛋白是因为你需要它,胰岛素是一种激素,它在糖代谢中起着非常重要的作用
-
A pancreas--cell in the pancreas, for example, needs to make insulin and so the gene for insulin is transcribed.
举个例子,一个胰腺细胞,要分泌胰岛素,那么编码胰岛素蛋白的基因就会被转录
-
The idea here is that when foods get ingested in the body, they create different responses from each other depending on how they affect insulin and blood sugar, blood sugar especially.
这个观点是,当食物被身体吸收时,它们产生各自不同反应取决于,它们如何影响胰岛素和血糖,特别是血糖
-
If it was directly transcribed there'd be regions that are important for making insulin and regions that are not.
如果直接转录的话,那被转录的序列中就会既包括了,和生成胰岛素有关的重要区域,也包括了与之无关的区域
-
Most cells in your body have insulin receptors so insulin is starting to bind to insulin receptors on those cells.
体内大多数细胞中都有胰岛素受体,胰岛素就开始与细胞上的胰岛素受体结合
-
When you don't produce enough insulin yourself, as diabetics do not, then you can use insulin as a drug.
如果你的体内不能产生足够的胰岛素,例如糖尿病人,你就可以将胰岛素作为药物使用
-
There are proteins, for example, on the surface of some cells that bind insulin and respond to the presence of insulin.
比如说蛋白,有些细胞表面上的蛋白,捕获胰岛素并且对胰岛素进行应答
-
Like we talked about with insulin; make large quantities of this recombinant viral protein, and use that as a vaccine.
就像我们讲过的胰岛素,生成大量重组的病毒蛋白,并将其作为疫苗使用
-
If I'm going to make insulin from this I have to know that I've got the introns spliced out correctly.
如果我要用这些来生成胰岛素,我就得知道是不是把内含子都准确剔除了
-
What insulin is doing inside your body is acting as a ligand for insulin receptors which stimulate certain kinds of cellular responses.
胰岛素在体内的功能就是作为,胰岛素受体的配体,刺激产生某种细胞效应
-
When it does your pancreas receives a signal that your blood glucose has started to go up, and it will secrete insulin.
这时你的胰腺会收到信号,你的血糖水平开始升高了,它就会分泌胰岛素
-
So you made somehow an anti-sense polynucleotide to the insulin gene or some fraction of the insulin gene.
这样你就合成了,胰岛素基因的反义多聚核苷酸链,或者说胰岛素基因的片段
-
So maybe - and here thinking about the pancreas has many functions but one of its important functions is to secrete insulin.
胰腺有很多的功能,其中最重要的功能之一,就是分泌胰岛素
-
Now I gave you the example of insulin and you probably wouldn't want to stop insulin production.
现在我以胰岛素为例,你们恐怕不会希望胰岛素合成被终止
-
There are more steps that have to happen correctly in order for that insulin to become active.
还有几个步骤,必须正确完成这些步骤后,才能生成有活性的胰岛素
-
So, there are cells in your pancreas which recognize glucose levels and they secrete insulin in response.
你的胰腺细胞能够,识别血糖水平,并分泌胰岛素作为反馈
-
Well, insulin is a protein, it's produced by cells in the pancreas, it circulates in your blood.
胰岛素是一种蛋白质,由胰腺细胞分泌,随着血液不断在体内循环
-
That means the gene that encodes insulin, the sequence of base pairs that encode insulin.
这意味着基因编码了胰岛素,碱基序列编码了胰岛素
-
Say we've got a human gene that we want to make and let's say it's the human gene for insulin that we want to produce now.
假设我们想合成出一个人类的基因,假设现在我们想合成的,是人类的胰岛素基因
-
When they do that, this insulin then starts to circulate throughout the blood.
当胰岛素开始分泌后,胰岛素就开始通过血液来循环
-
All the cells in your body have the gene for insulin in them.
所有人体细胞都有胰岛素基因
-
Insulin is important for regulating levels of sugar in your blood.
胰岛素的重要之处在于,它能够维持身体内血糖水平
-
What if you injected the gene for insulin into their muscle so that their muscle cells in one particular location started making insulin?
如果你把胰岛素基因注入到患者的肌肉中,使某个部位的肌肉,可以分泌胰岛素
-
In fact, for insulin, it's not the final version of the protein that comes out of translation.
事实上,就胰岛素而言,翻译完成后的形式,还不是蛋白质的最终形式
-
It gets enhanced because when insulin binds to the insulin receptor, it activates the receptor.
这种增强效应来自于,胰岛素与胰岛素受体结合后,就激活了该受体
-
They put a gene like the insulin gene in place of the milk protein, but behind the promoter that is used to produce milk proteins.
人们将产羊奶蛋白的基因,换成了胰岛素基因,在启动子后面的基因,原本是编码羊奶蛋白的
-
Go a little bit further with this schematic and talking about what insulin does.
我要说的东西离这个例子有点远,来讲讲胰岛素作用
-
Diabetics whose pancreas does not function properly, so don't make enough insulin, don't have enough insulin present for normal glucose metabolism so they can't handle sugars properly.
糖尿病人的胰脏功能失调,因此胰岛素分泌不足,影响了正常的血糖代谢,所以他们不能正常地调节血糖
-
I could cut that up into fragments, and I could search in these fragments to try to find the one that has the insulin gene on it.
我把那部分切成碎片,然后从中找到有胰岛素基因的那一段
-
Only cells in the pancreas, some cells in the pancreas are making insulin.
只有胰腺中的细胞,胰腺中的一些细胞分泌胰岛素
应用推荐