A big problem with this is a lot of Freudian theory is claimed to be validated in the course of psychoanalysis.

这里存在的一个大问题便是,精神分析理论中的很多内容,被认为是能够在精神分析的过程中,得到证实的。

耶鲁公开课 - 心理学导论课程节选

That's a big problem a lot, I think in group projects

我觉得这是很多团队项目当中的大问题，

怎么协调意见冲突 - SpeakingMax英语口语达人

That's a big problem and so can you protect these cells that you give to the recipient from attack by the recipient's immune system?

并且至关重要,那么你们想办法保护这些植入受体的细胞,使它们免受免疫系统的排异反应么

耶鲁公开课 - 生物医学工程探索课程节选

This is a big problem. -Interesting.

这可是个大问题，-挺有趣。

普林斯顿公开课 - 人性课程节选

It's kind of unsettling because we like to know what things are, but at the same time it's not really a big problem because as long as we know about the fact that a certain notion of literature exists in certain communities we can begin to do very interesting work precisely with that idea.

可能会有点让人不安，因为我们总想知道事物的定义，但知不知道,实际上问题不大,只要我们知道在特定群体中对文学有特定的认识,我们就能在这种认识上做文章。

耶鲁公开课 - 文学理论导论课程节选

But,there was a big problem, that for all of his failings,human failings, and there were indeed many, and his intellectual limitations which were daunting, he was a man of faith and loyalty to his principles, for better or for worse,in this context.

但是他的弱点,人性的弱点,是个大问题,而且他的弱点确实很多,还有他的智力界限也令人沮丧,他是个固执于自己原则的人,不管原则是好是坏

耶鲁公开课 - 1871年后的法国课程节选

But there's a big confound, there's a big problem in studies of those kind of relationships.

但是有一个让人混淆的问题,存在于这种关系的研究中。

耶鲁公开课 - 心理学导论课程节选

Portion sizes, and we'll devote a class to this later on, have gone way up and that's a big problem, the amount of processing I mentioned.

食物份量直线上升,这是个问题,我们将专门用一堂课讲这个,即刚才提到的食品加工程度的问题

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

So I hope it's not a big problem.

我希望不是什么大问题。

Is it okay 实战 - SpeakingMax英语口语达人

So if you're impure at home and just minding your own business, it's no big deal. It's only a problem if you decide you want to go to the sanctuary. So purity and impurity are states of qualification or disqualification for contact with sancta.

如果在家的时候不纯洁，一心只关注自己的事情，这倒不是什么大事，只有当你想去圣所的时候,才是个问题，因此纯洁和不纯洁只是表明了,你是否有资格接触圣所。

耶鲁公开课 - 旧约导论课程节选

We want to solve a really big problem.

我们想解决一个非常大的难题。

斯坦福公开课 - Twitter之父Jack.Dorsey演讲：好奇和灵感的力量课程节选

Taking the problem, recognizing that you know what, 8 even though this is a pretty big problem size 8 in this case and last time it was size 8 or in the case of the papers in size of a thousand roughly with the phonebook, I assume these are in a perfectly straight line they won't quite fit.

以这个问题为例，你们要认识到，在这种情况下，这是个比较大的问题，其大小是,上次它的大小也是8，但在纸片那个问题中,电话簿的规模大概是上千的，现在假设这些,杯子完全在同一条直线上，虽然并不十分符合这个条件。

哈佛公开课 - 计算机科学课程节选