AIDS is a tremendous problem, deaths from HIV infection and AIDS a tremendous problem in Africa and other parts of the world.

艾滋病是一个巨大的问题,在非洲和世界其他地方,艾滋病毒感染和艾滋病带来的死亡,是一个巨大的问题

耶鲁公开课 - 生物医学工程探索课程节选

The Hepatitis B subunit vaccine was produced at the same time that HIV-AIDS was being recognized as a problem in this country.

在乙肝亚基疫苗研制出来的同时,在该国家艾滋病开始被视为问题

耶鲁公开课 - 生物医学工程探索课程节选

Well, smallpox affected world history, it's--just as HIV infection is affecting world history now.

天花影响了世界历史,正如艾滋病现在正在影响世界历史

耶鲁公开课 - 生物医学工程探索课程节选

Viruses, you know about viruses; variola, we're going to talk about next week which causes smallpox, influenza, which causes the flu and HIV of course which cause AIDS are some examples.

病毒 你们都知道病毒,像天花病毒,我们下周会讲的引起天花的病毒,还有引起流感的流感病毒,引起艾滋病的人类免疫缺陷病毒等等

耶鲁公开课 - 生物医学工程探索课程节选

You know about retroviruses, the most famous and important one at this time is HIV, which is a retrovirus.

你们应该听过逆转录病毒吧,现下最为知名而重要的 HIV,就是一种逆转录病毒

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HIV is a member of the family of viruses called retroviruses, and retroviruses all use RNA as their genetic material.

IV是一种逆转录病毒,所有逆转录病毒均以RNA作为遗传物质

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For example, HIV enters cells of the immune system by binding to a receptor called CD4.

比如,HIV通过与CD4的受体结合,进入到免疫系统细胞中

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HIV, HIV is a natural virus that contains an enzyme in it.

IV,HIV是一种自然病毒,里面有一种酶

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HIV infection and AIDS is the one that comes first to mind, and is responsible for this slide, I think this is data from a few years ago, 700,000 deaths per year.

IV感染和艾滋病是我们第一个想到的,在这幅幻灯片上也提到了,我想这是几年前的数据了,每年死亡七十万人

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Because HIV is an RNA virus and if it enters your cell the only way it can replicate, it can put its DNA into your cells, is by first making DNA out of its RNA genome.

因为HIV是RNA病毒,如果它进入你的细胞,它复制自己的唯一方式,它能把自己的DNA转入你的细胞,方法是先用自己的,RNA基因组制造出DNA

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Reverse transcriptase is a naturally occurring protein, it has a biological function in HIV, but we can use it for a technical logical function here by going backwards on the biological path from messenger RNA to DNA.

反转录酶是在自然环境中存在的蛋白质,它在HIV中发挥着生物功能,但在这里它可以发挥一个技术功能,让它用信使RNA反转录出DNA

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We did not yet have good methods for screening blood to look for HIV, we didn't have the ELISA technique that I--we talked about in section a few weeks ago and so there was a great concern that there might be other diseases that you'd be passing on from-- unknowingly from this subset of patients that you're isolating the vaccine from.

那时我们还没有一种好的方式,来从血液中筛查出HIV,也还没有ELISA技术,该技术我们在几周前的一个章节中谈到过,因此,那时仍存有,很大的担心,那就是你有可能,在不知情的情况下,被那些病人,感染上其它疾病,因为疫苗就是从他们身上提取出来的

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