What a kinase enzyme does is that it recognizes this protein, and for example, the tyrosine that's on the protein.

激酶能够识别这类蛋白,例如,包含酪氨酸的蛋白

耶鲁公开课 - 生物医学工程探索课程节选

Well, if this kinase happens to turn this protein on then you would like to have a mechanism to turn it off as well.

那么在激酶激活蛋白质后,你会希望有一种方法能够使它失活

耶鲁公开课 - 生物医学工程探索课程节选

It generates a kinase activity which leads to phosphorylation of the protein.

它产生了一种激酶活性,导致了受体蛋白的磷酸化

耶鲁公开课 - 生物医学工程探索课程节选

There are 100 of these molecules, when a receptor gets activated a kinase activity gets activated, the kinase acts on the protein, the protein gets switched on, something new starts to happen inside the cell.

有一百个这样的分子,当受体被激活,激酶被激活后,激酶作用于蛋白,使蛋白活化,细胞中就会发生一些新变化

耶鲁公开课 - 生物医学工程探索课程节选

Another family is receptor tyrosine kinases, I'll show another picture in a moment that tells you more about what a kinase is, but a kinase is basically an enzyme that can add a phosphorous to another molecule.

另一类是酪氨酸激酶受体,马上我给你们看另一张图,这张图会更详细地告诉你们激酶是什么,激酶是一种能够,向其他分子上添加磷酸基团的酶

耶鲁公开课 - 生物医学工程探索课程节选

In this case, a receptor tyrosine kinase is a receptor molecule that binds a ligand at its surface outside the cell and initiates this enzyme activity - this kinase activity - and causes phosphorylation of another molecule.

在这个例子中,酪氨酸激酶受体可以,在细胞表面区域与配体结合,从而激发出,激酶的活性,使其能够磷酸化另一类分子

耶鲁公开课 - 生物医学工程探索课程节选

Insulin, the ligand binds to its receptor, creates a change through a kinase activity that's exposed, which leads to other biochemical changes, which leads to a change in cell behavior - in this case the cell behavior is that more glucose transporters are brought to the membrane and more glucose can enter the cell.

胰岛素,一种能够与受体结合的配体,通过其暴露出的激酶活性引起的变化,导致了其它后续生化变化的发生,进而使细胞行为发生改变,这个例子中的细胞行为就是,更多的糖载体被带到细胞膜表面,这样更多的糖分子进入到细胞内部

耶鲁公开课 - 生物医学工程探索课程节选