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Another example is in the nervous system, patients that have Parkinson's disease have too little of a natural ligand called dopamine.
另一个例子有关神经系统,帕金森氏病的患者,缺乏一种叫做多巴胺的天然的配体
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They prevent the ligand from reaching its natural receptor, and so that antagonizes or inhibits the function of the natural ligand.
它们能够阻止配体与受体的结合,这样就拮抗或者说是抑制了配体的功能
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That ligand was one for which the cell had a receptor that further encouraged it to produce more of the ligand.
对于带有对应受体的细胞来说,这种配体能够刺激细胞产生更多的配体
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What are - this understanding of receptor-ligand interactions has been really the biological basis of much of the pharmaceutical industry.
受体-配体相互作用理论,现在已经成为很多,制药工业的生物学基础
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What insulin is doing inside your body is acting as a ligand for insulin receptors which stimulate certain kinds of cellular responses.
胰岛素在体内的功能就是作为,胰岛素受体的配体,刺激产生某种细胞效应
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All of the molecules are called hormones, so a hormone is another name for a ligand that operates in this endocrine fashion.
这些分子都叫做激素,那么激素就是在内分泌系统中,起作用的配体的另一种叫法
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In the presence of this ligand, this molecule, it's open, it allows transport of this ion, when the ligand is gone it doesn't.
配体存在的情况下通道才打开,允许这些离子穿过,配体离开后,这些离子就不能通过了
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In the case of a ligand-receptor, a chemical signal in the form of a concentration of ligand gets converted into a biochemical signal.
在配体-受体系统中,配体浓度这种化学信号,转化为生化信号
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They bind sometimes better than the natural ligand does, but they don't create the right biological reaction.
结合的比天然配体和受体的的结合更紧密,但不能产生相同的生物效应
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Depending on which cell you are you would call one the 'receptor' and the other the 'ligand'.
这取决于你将哪种细胞上的分子,称为受体,哪种称为配体
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An agonist is a substance that mimics the action of a natural ligand, and I show you a couple of examples of agonists here.
激动剂是能够模拟天然配体分子的物质,在这里我给出了一些激动剂作为例子
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Now, sometimes the agonist is the natural ligand itself and that's - an example of that is when you use insulin as a drug.
有时激动剂药物就是天然配体分子,例如将胰岛素作为药物使用
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It has a gate on it and that gate is in open or close state depending on whether a ligand is present or not.
在这个通道上有个门,这个门是打开还是关闭,取决于配体到来与否
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For example, what if I activated this cell by encouraging it to produce this particular ligand?
如果促使细胞产生这种特定的配体,以此来激活细胞 会出现什么结果
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Sometimes you can design drugs that act like a natural ligand without being the natural ligand.
有时你能设计具有天然配体功能的药物,但它不一定和天然配体相同
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This would an example of a substance that inhibits the action of a natural ligand and they can inhibit in a variety of ways.
这类物质能够以多种方式,抑制天然配体的作用
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Those receptors, some fraction of them, are specific for the ligand that the pre-synaptic cell releases.
这些受体 其中一部分,特异性地结合突触前细胞释放的配体
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If a ligand comes and interacts with a receptor, it opens up; In the presence of this ligand, if the ligand goes away, it closes.
如果配体与受体相互作用,在配体存在的情况下通道打开,如果配体脱离,通道就关闭
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This is, maybe, the strangest because the ligand that stimulates the receptor is produced by the cell itself; so sometimes cells make signals that they receive.
它可能是最奇特的,因为激活受体的配体,是由细胞自身产生的,有时细胞产生让自己接受的信号
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There's a diverse range of responses that might occur, but that response is initiated by this simple chemical process of a ligand binding to a receptor.
细胞对外界信号可能会发生不同的反应,但这些反应都源自,配体和受体结合这个简单的化学过程
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All of them could potentially be receiving signals from a ligand or a chemical.
它们全都能接收,由配体或某种化学物质传递的信号
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Here, there are receptors on one cell and the ligand that they experience is not a dissolved molecule, but actually a molecule that's attached to another cell.
这个细胞上有许多受体,与之结合的配体并非是可溶性分子,而是一个附着在其他细胞上的分子
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The one that's on the top here is called ligand-gated ion channel and an ion channel is a protein that sits in the surface of a cell.
最上面的这个叫作配体门控离子通道,离子通道是一类位于细胞表面的蛋白
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Sometimes they inhibit by just preventing the ligand from interacting with its receptor.
有时它们只是,干扰配体和受体的相互作用
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If you think about receptor ligand system as an input into the cell.
如果将受体-配体系统看作,细胞的一种输入机制的话
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A hormone is just a ligand that operates in this endocrine fashion.
激素只是一种,在内分泌系统中起作用的配体
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So, they bind to the receptor - they occupy the receptor so now the natural ligand can't enter it but they don't create the same sequence of biochemical events.
因此,它们与受体结合,它们占据了受体,这样配体就进不来了,但这种结合无法诱发,真正的配体所能诱发的生化反应
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Just curious; before the ligand perimeter where are they stored?
只是好奇,配体释放到周围前储存在哪
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In some cases it might be a ligand-gated ion channel.
有时受体可能是一个配体门控离子通道
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This terminology 'ligand' and 'receptor' you've probably heard before.
你们可能听过配体和受体这两个术语
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