When estrogen is present it can enter cells in the vicinity and it can bind to receptors that are deep inside cells.

雌激素能够进入到邻近的细胞中,并能够与细胞内部的受体相结合

耶鲁公开课 - 生物医学工程探索课程节选

An example of a drug that works like that is the anti-cancer drug Tamoxifen which binds to estrogen receptors and blocks estrogen signaling.

这种药物的一个例子就是他莫昔芬,这是一种抗癌药,能够与雌激素受体结合,阻断雌激素信号通路

耶鲁公开课 - 生物医学工程探索课程节选