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It's a single gene defect and we know exactly where the genetic defect is in sickle cell.
是一种单基因缺陷,而且我们准确地知道,镰状红细胞贫血的基因缺陷在哪里
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It's on the gene for hemoglobin and the hemoglobin that you produce if you have sickle cell anemia is not quite right because there's one base difference.
这个缺陷基因和血红蛋白有关,如果你有镰状红细胞贫血症,那你所产生的血红蛋白就不太正常,因为这里有一个碱基不同
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Sickle cell anemia is a disease that affects a subset of the population.
镰状红细胞贫血症,是一种作用于特定人群的疾病
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We talked about sickle cell anemia last time, that's an example.
上次我们讲过镰刀状贫血病,那就是一例
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This particular example involves the gene for sickle cell anemia.
本例子中就包括镰状红细胞贫血症的基因
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In a normal cell DNA that DNA in the normal cell - this DNA gets cut by the restriction enzyme, so the sickle gene ends up - so that hemoglobin gene ends up in two pieces.
一个正常细胞的DNA,正常细胞里的DNA,会被限制酶所剪切,因此镰状血红蛋白基因--,不对,是正常血红蛋白基因被切成两段
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